Animal Models for Francisella tularensis and Burkholderia Species
| Autor: | Christopher R. Houchens, A. Pierce Smith, M. V. Stundick, M. T. Albrecht, T. M. Dreier, Josh Larsen |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
Burkholderia
medicine.drug_class Antibiotics Levofloxacin Computational biology Burkholderia mallei Animal model Ciprofloxacin medicine Animals Francisella tularensis Drug Approval Tularemia Biodefense General Veterinary biology United States Food and Drug Administration Burkholderia pseudomallei Burkholderia Infections biology.organism_classification United States Anti-Bacterial Agents Disease Models Animal Immunology Government Regulation bacteria Francisella |
| Zdroj: | Veterinary Pathology. 50:877-892 |
| ISSN: | 1544-2217 0300-9858 |
| DOI: | 10.1177/0300985813486812 |
| Popis: | The development and regulatory approval of medical countermeasures (MCMs) for the treatment and prevention of bacterial threat agent infections will require the evaluation of products in animal models. To obtain regulatory approval, these models must accurately recapitulate aspects of human disease, including, but not necessarily limited to, route of exposure, time to disease onset, pathology, immune response, and mortality. This article focuses on the state of animal model development for 3 agents for which models are largely immature: Francisella tularensis, Burkholderia mallei, and Burkholderia pseudomallei. An overview of available models and a description of scientific and regulatory gaps are provided. |
| Databáze: | OpenAIRE |
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