Palladium(ii )-catalyzed synthesis of indenones through the cyclization of benzenecarbaldehydes with internal alkynes
| Autor: | Rathod Aravind Kumar, Jajula Kashanna, Ravada Kishore |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Annulation Nucleophilic addition General Chemical Engineering chemistry.chemical_element Regioselectivity 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Medicinal chemistry Aldehyde 0104 chemical sciences Transmetalation chemistry.chemical_compound chemistry Organopalladium Intramolecular force 0210 nano-technology Palladium |
| Zdroj: | RSC Advances. 9:31162-31168 |
| ISSN: | 2046-2069 |
| Popis: | The palladium(II)-catalyzed carbocyclization of benzenecarbaldehydes with internal alkynes to afford 2,3-disubstituted indenones was reported. The annulation reaction proceeded through the transmetalation of Pd(II) with an aromatic aldehyde and the insertion of internal alkynes, followed by cyclization via the intramolecular nucleophilic addition of intermediate organopalladium(II) species to the aldehyde group. This reaction proceeded in moderate to good yields with high regioselectivity. |
| Databáze: | OpenAIRE |
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