Mirtazapine Improves Alcohol Detoxification
| Autor: | John Liappas, P. Malitas, George N. Christodoulou, Thomas Paparrigopoulos, Elias Tzavellas |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
Adult
Male Adolescent Temperance medicine.medical_treatment Mirtazapine Alcohol abuse Alcohol Mianserin Antidepressive Agents Tricyclic law.invention 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Randomized controlled trial law Detoxification medicine Humans Pharmacology (medical) Psychiatric Status Rating Scales Pharmacology Standard treatment Alcohol detoxification Middle Aged medicine.disease Combined Modality Therapy Substance Withdrawal Syndrome 030227 psychiatry Psychotherapy Alcoholism Psychiatry and Mental health Treatment Outcome chemistry Anesthesia Anxiety Female medicine.symptom Psychology 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Journal of Psychopharmacology. 18:88-93 |
| ISSN: | 1461-7285 0269-8811 |
| Popis: | The objective of the present study was to determine whether a combined psychotherapeutic–psychopharmacological (with mirtazapine) treatment of collateral anxiety and depressive symptomatology during the post-withdrawal phase of alcoholism facilitates the process of alcohol detoxification, which is a decisive stage in the treatment of alcohol-dependent individuals. For that purpose, the rate of remission of anxiety and depressive symptoms over a 4-week detoxification period was evaluated between two groups: the first group followed a standard detoxification protocol ( n = 33) and the second group was assigned to mirtazapine in addition to standard treatment ( n= 35). A marked reduction of anxiety and depressive symptoms was demonstrated in both groups. However, patients on mirtazapine improved more and at a faster rate compared to controls. Thus, mirtazapine, used adjunctively to short-term psychotherapy, may help the detoxification process by minimizing physical and subjective discomfort. Consequently, it may improve patient compliance in alcohol detoxification programs and facilitate the initial phase treatment of alcohol abuse dependence. |
| Databáze: | OpenAIRE |
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