Bis(2,2,2-trifluoroethyl) Carbonate as a Condensing Agent in One-Pot Parallel Synthesis of Unsymmetrical Aliphatic Ureas

Autor:	Andrey V. Bogolubsky, Pavel K. Mykhailiuk, Sergey E. Pipko, Roman Doroschuk, Dmitry S. Granat, Yurii S. Moroz, Anzhelika I. Konovets, Andrey A. Tolmachev
Rok vydání:	2014
Předmět:	chemistry.chemical_classification chemistry.chemical_compound Molecular Structure Chemistry Urea Carbonate Organic chemistry Esters General Chemistry General Medicine Alkyl
Zdroj:	ACS Combinatorial Science. 16:303-308
ISSN:	2156-8944 2156-8952
DOI:	10.1021/co500025f
Popis:	One-pot parallel synthesis of unsymmetrical aliphatic ureas was achieved with bis(2,2,2-trifluoroethyl) carbonate. The procedure worked well for both the monosubstituted and functionalized alkyl amines and required no special conditions (temperature control, order, or rate of addition). A library of 96 diverse ureas was easily synthesized.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a67c954fc7a88da411a603199fa8c8a https://doi.org/10.1021/co500025f Zobrazit plný text záznamu