Pitfalls of toxicological investigations in hair, bones, and nails in extensively decomposed bodies: illustration with two cases
| Autor: | Wiart, J-F. (Jean-Francois), Hakim, F. (Florian), Andry, A. (Aude), Eiden, C. (Celine), Drevin, G. (Guillaume), Lelievre, B. (Benedicte), Rouge-Maillart, C. (Clotilde), Decourcelle, M. (Marie), Lemaire-Hurtel, A-S. (Anne-Sophie), Allorge, D. (Delphine), Gaulier, J-M. (Jean-Michel), hakim fl |
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| Přispěvatelé: | Toxicologie et Génopathies [CHRU Lille], Pôle de Biologie Pathologie Génétique [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille)-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Groupe d'Étude des Interactions Hôte-Pathogène (GEIHP), Université d'Angers (UA), Centre Jean Bodin : Recherche Juridique et Politique (CJB), Impact de l'environnement chimique sur la santé humaine - ULR 4483 (IMPECS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), CHU Lille, Institut Pasteur de Lille, Université de Lille, IMPact de l'Environnement Chimique sur la Santé humaine (IMPECS) - ULR 4483, Centre Hospitalier Régional Universitaire [Lille] [CHRU Lille], Impact de l'environnement chimique sur la santé humaine - ULR 4483 [IMPECS], Département de Pharmacologie-Toxicologie [CHU Angers], Centre Hospitalier Universitaire d'Angers [CHU Angers], CHU Amiens-Picardie |
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
integumentary system
business.industry [SDV]Life Sciences [q-bio] 010401 analytical chemistry Postmortem period Physiology Lormetazepam 01 natural sciences 0104 chemical sciences Pathology and Forensic Medicine Time of death Bone Hair Toxicology Putrefaction Nails Forensic 03 medical and health sciences 0302 clinical medicine Oxazepam [SDV.TOX]Life Sciences [q-bio]/Toxicology Medicine 030216 legal & forensic medicine business ComputingMilieux_MISCELLANEOUS medicine.drug |
| Zdroj: | International Journal of Legal Medicine International Journal of Legal Medicine, Springer Verlag, 2020, ⟨10.1007/s00414-020-02267-3⟩ International Journal of Legal Medicine, 2020, ⟨10.1007/s00414-020-02267-3⟩ |
| ISSN: | 0937-9827 |
| DOI: | 10.1007/s00414-020-02267-3⟩ |
| Popis: | It is difficult to carry out toxicological investigations in biological samples collected from extensively decomposed bodies and to interpret obtained results as several pitfalls should be considered: redistribution phenomena, degradation of xenobiotics during the postmortem period, contamination by putrefaction fluids, and external contamination. This work aims to present two cases in order to illustrate and discuss these difficulties in this tricky situation. Case#1: the body of a 30-year-old woman was found in a wooded area (1 month after she has been reported missing by her family): hair and a femur section were sampled. Case#2: the decomposed corpse of a 52-year-old man was found in a ditch: hair and nails were sampled. After decontamination steps, toxicological investigations were performed using liquid chromatography with high-resolution mass spectrometry and tandem mass spectrometry detection methods. In case#1, the same drugs or metabolites (benzodiazepines, propranolol, tramadol, acetaminophen, paroxetine, and oxetorone) were detected in hair and in bone specimens. This result combination strongly suggests intakes close to the time of death for three of them (oxazepam, lormetazepam, and propranolol). In case#2, results of toxicological investigations in hair and nails [(hair/nail concentration in ng/mg) nordiazepam (1.12/1.06), oxazepam (0.113/0.042), zolpidem (0.211/ |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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