Retinoids and spermatogenesis: lessons from mutant mice lacking the plasma retinol binding protein

Autor: Norbert Giese, Manuel Mark, Stéphane Viville, Heinz Nau, Christine Dennefeld, Nadège Vernet, Norbert B. Ghyselinck, Pierre Chambon
Přispěvatelé: Institut de génétique et biologie moléculaire et cellulaire (IGBMC), Université Louis Pasteur - Strasbourg I-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Louis Pasteur - Strasbourg I
Jazyk: angličtina
Rok vydání: 2006
Předmět:
Male
medicine.medical_specialty
endocrine system
Spermiogenesis
Retinoic acid
Context (language use)
Biology
MESH: Gene Targeting
Mice
Retinoids
03 medical and health sciences
Paracrine signalling
chemistry.chemical_compound
MESH: Mice
Inbred C57BL
Internal medicine
medicine
Animals
MESH: Animals
MESH: Retinoids
Spermatogenesis
Vitamin A
MESH: Mice
MESH: Vitamin A
030304 developmental biology
0303 health sciences
Spermatid
urogenital system
030302 biochemistry & molecular biology
[SDV.BBM.BM]Life Sciences [q-bio]/Biochemistry
Molecular Biology/Molecular biology
Sertoli cell
MESH: Retinol-Binding Proteins
MESH: Male
Cell biology
Mice
Inbred C57BL
Retinol-Binding Proteins
medicine.anatomical_structure
Endocrinology
Nuclear receptor
chemistry
Gene Targeting
Retinol-Binding Proteins
Plasma
MESH: Spermatogenesis
Developmental Biology
Zdroj: Developmental Dynamics
Developmental Dynamics, Wiley, 2006, 235 (6), pp.1608-22. ⟨10.1002/dvdy.20795⟩
ISSN: 1058-8388
1097-0177
DOI: 10.1002/dvdy.20795⟩
Popis: International audience; Using Rbp4-null mice as models, we have established for the first time the kinetics of the spermatogenetic alterations during vitamin A deficiency (VAD). Our data demonstrate that the VAD-induced testicular degeneration arises through the normal maturation of germ cells in a context of spermatogonia differentiation arrest. They indicate that retinoic acid (RA) appears dispensable for the transition of premeiotic to meiotic spermatocytes, meiosis, and spermiogenesis. They confirm that RA plays critical roles in controlling spermatogonia differentiation, spermatid adhesion to Sertoli cells, and spermiation, and suggest that the VAD-induced arrest of spermatogonia differentiation results from simultaneous blocks in RA-dependent events mediated by RA receptor gamma (RARgamma) in spermatogonia and by RARalpha in Sertoli cells. They also provide evidence that expression of major RA-metabolizing enzymes is increased in mouse Sertoli cells upon VAD and that vitamin A-deficient A spermatogonia differ from their RA-sufficient counterparts by the expression of the Stra8 gene.
Databáze: OpenAIRE
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