Laser therapy in oral mucositis control: a meta-analysis
| Autor: | Liliane Lins, Ana Carolina Esteves Cattony, André Luiz Peixoto Figueiredo, Antônio Fernando Pereira Falcão |
|---|---|
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Laser terapia business.industry Prevention MEDLINE Odds ratio medicine.disease Surgery Oral mucositis Meta-analysis Metanálise Laser therapy Sample size determination Internal medicine Mucosite oral Mucositis medicine General Earth and Planetary Sciences Statistical analysis In patient Prevenção business General Environmental Science |
| Zdroj: | Revista da Associação Médica Brasileira (English Edition). 59:467-474 |
| ISSN: | 2255-4823 |
| DOI: | 10.1016/s2255-4823(13)70506-x |
| Popis: | Objective To perform a systematic review and meta-analysis of the effectiveness of laser therapy (LT) in the prevention of oral mucositis (OM) in patients undergoing oncotherapy. Methods A search was conducted in the MEDLINE, LILACS, and Cochrane databases using the keywords “laser therapy” and “oral mucositis” in order to perform this systematic review and meta-analysis. The case-control studies included were submitted to odds ratio (OR) analysis, whose cut-off for statistic calculation was OM grade ≥ 3. Calculations were performed with the BioEstat program, release 5.0, using DerSimonian-Laird's random effects statistical analysis. Results In this systematic review, twelve studies were included; the meta-analysis of seven of them demonstrated that LT in patients undergoing oncotherapy is approximately 10 times more effective in the prevention of OM grade ≥ 3 than in patients without laser treatment (OR: 9.5281; 95% CI: 1.447-52.0354; p = 0.0093). Conclusion The data demonstrated the significant prophylactic effect of OM grade ≥ 3 in patients undergoing LT. Further studies, with larger sample sizes, are needed for better evaluation of LT's prophylactic effect on OM grade ≥ 3. |
| Databáze: | OpenAIRE |
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