Effects of Apigenin on Experimental Ischemia/Reperfusion Injury in the Rat Ovary
| Autor: | Z Soyman, Sefa Kelekci, Nihan Bayindir, Hafize Uzun, Osman Sevket, Sal |
|---|---|
| Přispěvatelé: | BAYINDIR, NİHAN |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
Anti-mullerian hormone Ischemia lcsh:Medicine Ovary 010501 environmental sciences Anti-mullerian hormone apigenin ischemia/reperfusion injury ovary rat medicine.disease_cause Nitric Oxide ischemia/reperfusion injury 01 natural sciences Nitric oxide chemistry.chemical_compound Internal medicine medicine Animals rat Ovarian Diseases Rats Wistar 0105 earth and related environmental sciences apigenin business.industry lcsh:R 0402 animal and dairy science 04 agricultural and veterinary sciences General Medicine Glutathione medicine.disease Malondialdehyde 040201 dairy & animal science SOYMAN Z. KELEKCI S. SAL V. Şevket O. BAYıNDıR N. UZUN H. -Effects of Apigenin on Experimental Ischemia/Reperfusion Injury in the Rat Ovary.- Balkan medical journal cilt.34 ss.444-449 2017 Rats Disease Models Animal Endocrinology medicine.anatomical_structure anti-Müllerian hormone chemistry Reperfusion Injury Apigenin Female Original Article ovary business Reperfusion injury Oxidative stress |
| Zdroj: | Balkan Medical Journal, Vol 34, Iss 5, Pp 444-449 (2017) Balkan Medical Journal Volume: 34, Issue: 5 444-449 |
| ISSN: | 2146-3131 2146-3123 |
| Popis: | Apigenin is a plant-derived compound belonging to the flavone class, which possess antioxidant, free-radical-scavenging and anti-inflammatory properties. Administration of apigenin has no significant protective effect on ovarian reserve and tissue damage in ovarian ischemia/reperfusion injury Background: Apigenin is a plant-derived compound belonging to the flavone class, which possess antioxidant, free-radical-scavenging and anti-inflammatory properties. Aims: To address the effects of apigenin on serum anti-mullerian hormone levels, tissue oxidative stress parameters and histopathological changes in ovarian ischemia/reperfusion injury. Study Design: Animal experiment. Methods: Twenty-eight female Wistar albino rats were randomly separated into four sections: Sham operation (group 1), ischemia/reperfusion plus saline (group 2), ischemia/reperfusion plus dimethyl sulfoxide (group 3) and ischemia/reperfusion plus apigenin (group 4). In all ischemia/reperfusion groups, a bilateral adnexal 3-h period of ischemia was performed, followed by 3-h of reperfusion. A single dose of 15 mg/kg apigenin was given intraperitoneally 60 min before reperfusion in group 4. After 3-h of reperfusion, both ovaries were removed, and blood samples were collected. The main outcome measures were serum anti-mullerian hormone levels, ovarian tissue malondialdehyde, total nitric oxide, Cu/Zn superoxide dismutase, catalase and glutathione levels and histopathological damage scores. Results: The ovarian tissue nitric oxide level was significantly lower, and the glutathione level was significantly higher in group 4 compared with groups 2 and 3. There was no significant difference in anti-mullerian hormone levels among the three ischemia/reperfusion groups. The histopathological damage score was lower in group 4 than in groups 2 and 3 (p>0.05). Conclusion: Administration of apigenin has no significant protective effect on ovarian reserve and tissue damage in ovarian ischemia/reperfusion injury. |
| Databáze: | OpenAIRE |
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