Detection of crown-like structures in breast adipose tissue and clinical outcomes among African-American and White women with breast cancer

Autor: Mark E. Sherman, Jiabei He, Yuan Liu, Keerthi Gogineni, Jasmine Miller-Kleinhenz, Maret L. Maliniak, Jinjing He, Lauren E. McCullough, Aswathy M Cheriyan, Uma Krishnamurti, Jiaqi Liu, Ryan Ashiqueali, Rami Yacoub
Rok vydání: 2020
Předmět:
Oncology
Adult
medicine.medical_specialty
medicine.medical_treatment
Adipose tissue
Breast Neoplasms
lcsh:RC254-282
White People
03 medical and health sciences
Young Adult
0302 clinical medicine
Breast cancer
Internal medicine
medicine
Humans
Breast adipose tissue
Progression-free survival
Obesity
030304 developmental biology
Aged
Aged
80 and over
0303 health sciences
Proportional hazards model
business.industry
Hazard ratio
Middle Aged
medicine.disease
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
Prognosis
Combined Modality Therapy
Confidence interval
Black or African American
Survival Rate
Breast cancer outcome disparity
Adipose Tissue
Receptors
Estrogen
030220 oncology & carcinogenesis
Crown-like structures
Female
business
Mastectomy
Follow-Up Studies
Research Article
Zdroj: Breast Cancer Research : BCR
Breast Cancer Research, Vol 22, Iss 1, Pp 1-13 (2020)
ISSN: 1465-542X
Popis: Background Crown-like structures in breast adipose tissue (CLS-B), composed of necrotic adipocytes encircled by macrophages, are associated with obesity and hypothesized to worsen breast cancer prognosis; however, data are sparse, particularly in multi-racial populations. Methods We assessed specimens for CLS-B from 174 African-American and 168 White women with stage I–III breast cancer treated by mastectomy. Benign breast tissue from an uninvolved quadrant was immunohistochemically stained for CD68 to determine CLS-B presence and density (per cm2 of adipose tissue). Demographic and lifestyle factors, collected via medical record review, were analyzed for associations with CLS-B using logistic regression. Multivariable Cox proportional hazards models were used to compute hazard ratios (HRs) and 95% confidence intervals (CIs) for associations between CLS-B and overall (OS) or progression-free (PFS) survival. Results Detection of any CLS-B was similar between African-American (32%) and White (29%) patients with no evidence of an association between race and CLS-B in multivariable models (OR = 0.82, 95% CI = 0.49–1.36). Detection of CLS-B was associated with obesity (OR = 4.73, 95% CI = 2.48–9.01) and age ≥ 60 years at diagnosis (OR = 1.78, 95% CI = 0.99–3.21). There was some evidence of associations with parity and current smoking status. Detection of CLS-B was not associated with OS (HR = 1.02, 95% CI = 0.55–1.87) or PFS (HR = 0.99, 95% CI = 0.59–1.67). Conclusions Our results show a strong, positive association between BMI and CLS-B in non-tumor tissue similar to previous findings. Detection of CLS-B did not vary by race and was not associated with worse OS or PFS.
Databáze: OpenAIRE
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