Plasma alkylresorcinol concentrations, biomarkers of whole-grain wheat and rye intake, in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
| Autor: | Tilman Kühn, Lene Angell Åsli, Paula Jakszyn, Marie-Christine Boutron-Ruault, Per Åman, Vincent K. Dik, Cecilie Kyrø, Neil Murphy, Elisabete Weiderpass, Jane Christensen, Pilar Amiano, Vanessa Cottet, Heinz Freisling, Ruth C. Travis, Anja Olsen, Peter D. Siersema, Kay-Tee Khaw, Steffen Loft, Jenny Chang-Claude, Paolo Vineis, Valeria Pala, Nicholas J. Wareham, Guri Skeie, Ingrid Ljuslinder, Kim Overvad, Tobias Pischon, Guy Fagherazzi, Antonia Trichopoulou, Rosario Tumino, Heiner Boeing, Rikard Landberg, Giovanna Masala, Elio Riboli, Nadia Slimani, Anne Tjønneland, Soledad Sánchez, Petra H.M. Peeters, Pietro Ferrari, Androniki Naska, Despoina Oikonomidou, Timothy J. Key, Amalia Mattiello, Aurelio Barricarte, Toril Bakken, Max Leenders, José María Huerta, Richard Palmqvist, H. B. Bueno-de-Mesquita, María José Sánchez, Marc J. Gunter |
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| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
Dietary Fiber
Male Medicine (miscellaneous) Type 2 diabetes Biology Lower risk Whole grains Alkylresorcinol medicine Humans Prospective Studies Food science Prospective cohort study Triticum Aged Nutrition and Dietetics Secale Case-control study food and beverages Resorcinols Middle Aged medicine.disease Diet European Prospective Investigation into Cancer and Nutrition Europe Case-Control Studies Cohort Female Colorectal Neoplasms Biomarkers |
| Zdroj: | Kyrø, C, Olsen, A V, Bueno-de-Mesquita, H B A, Skeie, G, Loft, S, Aman, P, Leenders, M, Dik, V K, Siersema, P D, Pischon, T, Christensen, J, Overvad, K, Boutron-Ruault, M-C, Fagherazzi, G, Cottet, V, Kühn, T, Chang-Claude, J, Boeing, H, Trichopoulou, A, Naska, A, Oikonomidou, D, Masala, G, Pala, V, Tumino, R, Vineis, P, Mattiello, A, Peeters, P H, Bakken, T, Weiderpass, E, Asli, L A, Sánchez, S, Jakszyn, P, Sánchez, M-J, Amiano, P, Huerta, J M, Barricarte, A, Ljuslinder, I, Palmqvist, R, Khaw, K-T, Wareham, N, Key, T J, Travis, R C, Slimani, N, Freisling, H, Ferrari, P, Gunter, M J, Murphy, N, Riboli, E, Tjønneland, A & Landberg, R 2014, ' Plasma alkylresorcinol concentrations, biomarkers of whole-grain wheat and rye intake, in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort ', British Journal of Nutrition, vol. 111, no. 10, pp. 1881-90 . https://doi.org/10.1017/S0007114513004388 |
| Popis: | Whole-grain intake has been reported to be associated with a lower risk of several lifestyle-related diseases such as type 2 diabetes, CVD and some types of cancers. As measurement errors in self-reported whole-grain intake assessments can be substantial, dietary biomarkers are relevant to be used as complementary tools for dietary intake assessment. Alkylresorcinols (AR) are phenolic lipids found almost exclusively in whole-grain wheat and rye products among the commonly consumed foods and are considered as valid biomarkers of the intake of these products. In the present study, we analysed the plasma concentrations of five AR homologues in 2845 participants from ten European countries from a nested case-control study in the European Prospective Investigation into Cancer and Nutrition. High concentrations of plasma total AR were found in participants from Scandinavia and Central Europe and lower concentrations in those from the Mediterranean countries. The geometric mean plasma total AR concentrations were between 35 and 41Â nmol/l in samples drawn from fasting participants in the Central European and Scandinavian countries and below 23Â nmol/l in those of participants from the Mediterranean countries. The whole-grain source (wheat or rye) could be determined using the ratio of two of the homologues. The main source was wheat in Greece, Italy, the Netherlands and the UK, whereas rye was also consumed in considerable amounts in Germany, Denmark and Sweden. The present study demonstrates a considerable variation in the plasma concentrations of total AR and concentrations of AR homologues across ten European countries, reflecting both quantitative and qualitative differences in the intake of whole-grain wheat and rye. © 2014 The Authors. |
| Databáze: | OpenAIRE |
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