Restoration of renal responsiveness to atrial natriuretic peptide in experimental nephrotic syndrome by albumin infusion
| Autor: | Joseph Winaver, Ilia Goltsman, Tony Karram, Irit Weissman, Aaron B. Hoffman, Zaid Abassi, Ori S. Better |
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| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Nephrotic Syndrome medicine.medical_treatment Renal function Natriuresis Blood Pressure Kidney Renal Circulation Rats Sprague-Dawley Atrial natriuretic peptide Internal medicine Albumins Renin medicine Animals Edema Humans Hypoalbuminemia business.industry Sodium Albumin Inulin medicine.disease Rats Disease Models Animal Endocrinology Blood pressure Nephrology Doxorubicin cardiovascular system Nephrosis Salts Diuretic Hypotension business Nephrotic syndrome hormones hormone substitutes and hormone antagonists Atrial Natriuretic Factor Glomerular Filtration Rate |
| Zdroj: | American journal of nephrology. 38(4) |
| ISSN: | 1421-9670 |
| Popis: | Background: The natriuretic/diuretic response to atrial natriuretic peptide (ANP), an important regulator of water and Na+ balance, is markedly attenuated in nephrotic syndrome (NS). It has been suggested that the diminished renal responsiveness to ANP may contribute to the pathogenesis of salt retention and edema formation in NS. However, the mechanisms underlying the renal hyporesponsiveness to ANP remain largely unknown. Methods: The acute effects of exogenous infusion of ANP (5 µg/kg + 10 µg/kg/h) were studied by clearance methodology in control rats, hypoalbuminemic rats with Adriamycin (ADR)-induced NS and in ADR-treated rats infused with hyperoncotic albumin sufficient to restore plasma albumin to normal levels. Results: Administration of ANP to control rats resulted in a significant increase in urinary flow rate, absolute rate of sodium excretion (+456%) and glomerular filtration rate (GFR). Mean arterial blood pressure decreased following infusion of the peptide. In the nephrotic rats, baseline GFR and Na+ excretion were significantly lower than in the control animals, and the renal effects of ANP were markedly blunt compared to the control animals. In contrast, the hypotensive effect of ANP in the ADR-treated rats was largely preserved. Infusion of hyperoncotic albumin prior to ANP administration reversed the decrease in baseline GFR and Na+ excretion and completely restored the renal effects of ANP in the nephrotic rats. Conclusion: These findings indicate that renal hyporesponsiveness to ANP in rats with ADR-induced NS is a reversible phenomenon that appears to be of functional origin rather than reflecting permanent cellular damage. |
| Databáze: | OpenAIRE |
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