The effect of vaginal microbial communities on colonization by Staphylococcus aureus with the gene for toxic shock syndrome toxin 1 (TSST-1): a case–control study
| Autor: | Catherine C. Davis, Melanie A. Hansmann, Larry J. Forney, Jacob D. Pierson |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Adult
0301 basic medicine Microbiology (medical) Staphylococcus aureus Adolescent Bacterial Toxins 030106 microbiology Gene Expression Enterotoxin Biology medicine.disease_cause Staphylococcal infections Microbiology Enterotoxins 03 medical and health sciences RNA Ribosomal 16S medicine Superantigen Humans Immunology and Allergy Colonization Phylogeny Superantigens General Immunology and Microbiology Microbiota Toxic shock syndrome General Medicine Staphylococcal Infections bacterial infections and mycoses medicine.disease Shock Septic Menstruation Terminal restriction fragment length polymorphism Infectious Diseases medicine.anatomical_structure Case-Control Studies Carrier State Vagina Female Polymorphism Restriction Fragment Length Research Article |
| Zdroj: | Pathogens and Disease. 76 |
| ISSN: | 2049-632X |
| Popis: | Menstrual toxic shock syndrome is associated with vaginal colonization by Staphylococcus aureus strains that encode toxic shock syndrome toxin 1 (tst(+)). Interestingly, a small proportion of women are colonized by S. aureus tst(+) but do not have symptoms of toxic shock syndrome. Here we sought to determine if differences in the species composition of vaginal bacterial communities reflect a differential risk of colonization by S. aureus capable of producing toxic shock syndrome toxin 1 (TSST-1). The composition of vaginal communities of women that were or were not colonized with S. aureus tst(+) were compared based on terminal restriction fragment length polymorphism (T-RFLP) profiles and sequences of cloned 16S rRNA genes. There were no detectable differences in community composition or species rank abundance between communities of women vaginally colonized with S. aureus tst(+) as compared to those that were not. Phylogenetic analysis of cloned 16S rRNA gene sequences showed that the predominant members of communities of women colonized with S. aureus tst(+) were indistinguishable from those of other healthy women. The data suggest that the numerically dominant members of vaginal communities do not preclude colonization and proliferation of S. aureus tst(+) within indigenous microbial communities of the vagina. |
| Databáze: | OpenAIRE |
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