Fathead minnow exposed to environmentally relevant concentrations of metformin for one life cycle show no adverse effects
| Autor: | Stacey Clarence, Hufsa Khan, Joanne L. Parrott, Cheryl Sullivan, Mehran Alaee, Madelaine Gardiner, Kallie Shires, Grazina Pacepavicius |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
endocrine system diseases
010504 meteorology & atmospheric sciences growth Science Physiology Urine 010501 environmental sciences 01 natural sciences Education Vitellogenin biology.animal medicine pharmaceutical Adverse effect 0105 earth and related environmental sciences Multidisciplinary biology business.industry gonadosomatic index digestive oral and skin physiology nutritional and metabolic diseases egg production Minnow Metformin Gonadosomatic Index Wastewater fertilization biology.protein Pimephales promelas business vitellogenin medicine.drug |
| Zdroj: | FACETS, Vol 6, Iss 1, Pp 998-1023 (2021) |
| ISSN: | 2371-1671 |
| Popis: | Metformin is a glucose-lowering drug taken for diabetes. It is excreted by humans in urine and detected in municipal wastewater effluents and rivers. Fathead minnows ( Pimephales promelas) were exposed over a life cycle to measured concentrations of metformin: 3.0, 31, and 322 μg/L. No significant changes were observed in survival, maturation, growth, condition factor, or liver size. Relative ovary size of females exposed to 322 μg/L metformin was significantly larger than controls. There was no induction of vitellogenin in plasma of minnows, and gonad maturation was not statistically different from controls. The start of breeding was delayed by 9–10 d in the mid- and high metformin treatments (statistically significant only in the mid-concentration), but numbers and quality of eggs were not statistically different from controls. There were no effects of metformin on survival or growth of offspring. Exposure to metformin at environmentally relevant concentrations (i.e., 3.0 and 31 μg/L metformin) caused no adverse effects in fathead minnows exposed for a life cycle, with the exception of a delay in time to first breeding (that did not impact overall egg production). The results of the study are important to help understand whether metformin concentrations in rivers and lakes can harm fishes. |
| Databáze: | OpenAIRE |
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