Association between the maternal serum levels of 19 eicosanoids and pre-eclampsia
| Autor: | Qian Li, Shuaijun Lu, Anxiong Long, Yuli Zhu, Na Lin, Liansheng Jiang, Longyi Tan, Xia Zhan, Shungao Ma |
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| Rok vydání: | 2016 |
| Předmět: |
Adult
0301 basic medicine China Leukotriene B4 Physiology Epoxyeicosatrienoic acid Young Adult 03 medical and health sciences chemistry.chemical_compound Pre-Eclampsia Pregnancy Hydroxyeicosatetraenoic Acids Humans Medicine Young adult reproductive and urinary physiology Eclampsia business.industry Case-control study Obstetrics and Gynecology Hydroxyeicosatetraenoic acid hemic and immune systems General Medicine Serum samples medicine.disease 030104 developmental biology chemistry Biochemistry Case-Control Studies cardiovascular system Eicosanoids Female lipids (amino acids peptides and proteins) business |
| Zdroj: | International Journal of Gynecology & Obstetrics. 133:291-296 |
| ISSN: | 0020-7292 |
| DOI: | 10.1016/j.ijgo.2015.10.024 |
| Popis: | To investigate whether serum levels of 19 eicosanoids are associated with pre-eclampsia.A case-control study was performed using data for pregnant women with pre-eclampsia, normotensive pregnant women, and nonpregnant women, for all of whom serum samples had been collected at a hospital in Shanghai, China, between December 2012 and December 2013. Ultra-performance liquid chromatography-tandem mass spectrometry was used to measure the serum levels of 19 eicosanoids.Overall, 49 pregnant women with pre-eclampsia, 26 normotensive pregnant women, and 14 nonpregnant women were included. Women with pre-eclampsia had significantly higher serum levels of 11,12-epoxyeicosatrienoic acid (11,12-EET), the hydroxyeicosatetraenoic acids 5-HETE, 8-HETE, 12-HETE, and 15-HETE, and leukotriene B4 than did women with a normal pregnancy and nonpregnant women, both before and after the onset of pre-eclampsia (P0.01 for all comparisons). Women with severe pre-eclampsia had significantly higher serum levels of 5-HETE, 15-HETE, and leukotriene B4 than did women with mild pre-eclampsia, women with a normal pregnancy, and nonpregnant women (P0.01 for all comparisons).The eicosanoids 11,12-EET, 5-HETE, 8-HETE, 12-HETE, 15-HETE, and leukotriene B4 might play important parts in the occurrence and development of pre-eclampsia. |
| Databáze: | OpenAIRE |
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