Effects of chronic exercise and imipramine on mRNA for BDNF after olfactory bulbectomy in rat
| Autor: | Philip V. Holmes, Heather O. Chambliss, Rod K. Dishman, Jacqueline D. Van Hoomissen |
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| Rok vydání: | 2003 |
| Předmět: |
Male
medicine.medical_specialty Imipramine Central nervous system Physical Exertion Substantia nigra Nucleus accumbens Antidepressive Agents Tricyclic Running Internal medicine Piriform cortex Physical Conditioning Animal medicine Animals Rats Long-Evans RNA Messenger Molecular Biology In Situ Hybridization Brain-derived neurotrophic factor Brain Chemistry Behavior Animal business.industry General Neuroscience Brain-Derived Neurotrophic Factor Olfactory Bulb Olfactory bulb Rats Ventral tegmental area medicine.anatomical_structure Endocrinology nervous system Anesthesia Autoradiography Neurology (clinical) business Developmental Biology medicine.drug |
| Zdroj: | Brain research. 974(1-2) |
| ISSN: | 0006-8993 |
| Popis: | We examined the effects of chronic activity wheel running and antidepressant treatment on brain-derived neurotrophic factor (BDNF) messenger RNA (mRNA) in multiple brain regions—hippocampal formation (HF), ventral tegmental area/substantia nigra (VTA/SN), nucleus accumbens (NAc), and piriform cortex (PFx)—after bilateral olfactory bulbectomy (OBX). Male, Long-Evans rats ( n =72) underwent either sham or OBX surgery and were randomly divided into eight experimental groups in a 2 (sham vs. OBX)×2 (sedentary vs. activity wheel)×2 (saline vs. imipramine) factorial design. Animals were killed after 21 days of treatment. Drug×exercise interaction effects were observed for HF ( P =0.006–0.023) and VTA/SN ( P =0.021); exercise increased BDNF mRNA in the saline treated animals but not in the imipramine treated animals. OBX did not affect BDNF mRNA in the HF or VTA/SN ( P >0.05). BDNF mRNA levels in the PFx were not altered by exercise, drug, or OBX ( P >0.05). These results suggest that the effect of exercise on BDNF mRNA extends beyond the HF to the mesolimbic ventral tegmental area and that the potentiation of BDNF mRNA by exercise and antidepressant pharmacotherapy, reported by other investigators, is time limited. |
| Databáze: | OpenAIRE |
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