Functional definition of seizure provides new insight into post-traumatic epileptogenesis
| Autor: | Jeffrey G. Ojemann, Puneet Gupta, John W. Miller, Ramon Diaz-Arrastia, Clifford L. Eastman, Aaron H. Sheerin, Shahin Hakimian, Jason S. Fender, Raimondo D'Ambrosio, Derek R. Verley, Tessandra Stewart |
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| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Quality Control Traumatic brain injury Drug Resistance Electroencephalography Epileptogenesis Neurosurgical Procedures Rats Sprague-Dawley 03 medical and health sciences Epilepsy Young Adult 0302 clinical medicine Epilepsy Complex Partial Seizures Terminology as Topic Convulsion medicine Animals Humans Ictal Electrocorticography 030304 developmental biology 0303 health sciences medicine.diagnostic_test Behavior Animal traumatic brain injury biomarkers drug screening prophylaxis Original Articles Galvanic Skin Response Middle Aged medicine.disease Rats medicine.anatomical_structure Scalp Anesthesia Brain Injuries epileptogenesis Anticonvulsants Female Neurology (clinical) medicine.symptom Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Brain |
| ISSN: | 1460-2156 0006-8950 |
| Popis: | Experimental animals’ seizures are often defined arbitrarily based on duration, which may lead to misjudgement of the syndrome and failure to develop a cure. We employed a functional definition of seizures based on the clinical practice of observing epileptiform electrocorticography and simultaneous ictal behaviour, and examined post-traumatic epilepsy induced in rats by rostral parasagittal fluid percussion injury and epilepsy patients evaluated with invasive monitoring. We showed previously that rostral parasagittal fluid percussion injury induces different types of chronic recurrent spontaneous partial seizures that worsen in frequency and duration over the months post injury. However, a remarkable feature of rostral parasagittal fluid percussion injury is the occurrence, in the early months post injury, of brief ( |
| Databáze: | OpenAIRE |
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