The kallikrein-kinin pathway as a mechanism for auto-control of brown adipose tissue activity
| Autor: | Tania Quesada-López, Francesc Villarroya, Elena Kaschina, Rubén Cereijo, Marion Peyrou, Thomas Unger, Laura Campderrós, Laura Liñares-Pose, Marta Giralt, Miguel López, Aleix Gavaldà-Navarro |
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| Přispěvatelé: | RS: CARIM other |
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Adipose Tissue Brown/metabolism HIGH-FAT DIET BLOCKADE Receptor expression General Physics and Astronomy Fluorescent Antibody Technique Kinins ACTIVATION chemistry.chemical_compound Mice 0302 clinical medicine Adipose Tissue Brown Gene expression Brown adipose tissue Kinins/genetics Homeostasis BRADYKININ B1 Receptor lcsh:Science Mice Knockout Kininogen Multidisciplinary Blood proteins Endocrine system and metabolic diseases Kinin Kallikreins/genetics Kininogens/genetics Cell biology ADIPOCYTES medicine.anatomical_structure Proteïnes de la sang Kallikreins Fat metabolism circulatory and respiratory physiology Signal Transduction EXPRESSION animal structures Endocrine System/metabolism p38 mitogen-activated protein kinases Science Bradykinin 030209 endocrinology & metabolism Endocrine System Real-Time Polymerase Chain Reaction General Biochemistry Genetics and Molecular Biology Article 03 medical and health sciences B2 RECEPTORS medicine Animals Bradykinin/genetics Kininogens Adipose tissues General Chemistry GENE Mice Inbred C57BL Teixit adipós 030104 developmental biology chemistry Signal Transduction/genetics lcsh:Q WHITE RESISTANCE |
| Zdroj: | Nature Communications Dipòsit Digital de la UB Universidad de Barcelona Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020) Nature Communications, 11(1):2132. Nature Publishing Group Peyrou, M, Cereijo, R, Quesada-López, T, Campderrós, L, Gavaldà-Navarro, A, Liñares-Pose, L, Kaschina, E, Unger, T, López, M, Giralt, M & Villarroya, F 2020, ' The kallikrein-kinin pathway as a mechanism for auto-control of brown adipose tissue activity. ', Nature Communications, vol. 11, 2132 . https://doi.org/10.1038/s41467-020-16009-x |
| ISSN: | 2041-1723 |
| DOI: | 10.1038/s41467-020-16009-x |
| Popis: | Brown adipose tissue (BAT) is known to secrete regulatory factors in response to thermogenic stimuli. Components of the BAT secretome may exert local effects that contribute to BAT recruitment and activation. Here, we found that a thermogenic stimulus leads to enhanced secretion of kininogen (Kng) by BAT, owing to induction of kininogen 2 (Kng2) gene expression. Noradrenergic, cAMP-mediated signals induce KNG2 expression and release in brown adipocytes. Conversely, the expression of kinin receptors, that are activated by the Kng products bradykinin and [Des-Arg9]-bradykinin, are repressed by thermogenic activation of BAT in vivo and of brown adipocytes in vitro. Loss-of-function models for Kng (the circulating-Kng-deficient BN/Ka rat) and bradykinin (pharmacological inhibition of kinin receptors, kinin receptor-null mice) signaling were coincident in showing abnormal overactivation of BAT. Studies in vitro indicated that Kng and bradykinin exert repressive effects on brown adipocyte thermogenic activity by interfering the PKA/p38 MAPK pathway of control of Ucp1 gene transcription, whereas impaired kinin receptor expression enhances it. Our findings identify the kallikrein–kinin system as a relevant component of BAT thermogenic regulation that provides auto-regulatory inhibitory signaling to BAT. Brown adipose tissue, known produce heat by metabolizing fat, is also secretes molecules capable of communicating with other organs. Here the authors show that brown adipose tissue secretes kininogen, a component of heat system regulation, that provides auto-regulatory inhibitory signaling in brown adipose tissue. |
| Databáze: | OpenAIRE |
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