4-Acryloylmorpholine-Based Bottle Brush Polymers as Drug Carrier Candidate: Synthesis and Evaluation of Their Performance in Biological System

Autor:	SAGITA, ERNY
Rok vydání:	2021
Předmět:	FOS: Nanotechnology FOS: Chemical sciences technology industry and agriculture 100709 Nanomedicine 100708 Nanomaterials 30305 Polymerisation Mechanisms
DOI:	10.26180/14958066
Popis:	Many efforts have been made to improve current disease treatment, one of which uses a nano-carrier to help deliver an already-established drug. This thesis aimed to develop a platform of cylindrical shape polymeric nano-carrier using a simple and straightforward method of synthesis and purification. The produced polymeric nano-carriers demonstrated excellent physicochemical characteristics for use in biomedical application. In the pre-clinical studies in rodents they showed extended blood circulation, low accumulation in healthy organs and high disposition in tumour tissue. These promising results suggest the potency of our bottle-brush polymer as a new drug delivery carrier candidate for clinical application.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a581e9bbc8ebdcbcd621899186c6c24 Zobrazit plný text záznamu