Animal Models for Studying Triazole Resistance in Aspergillus fumigatus
| Autor: | Paul E. Verweij, Russell E. Lewis |
|---|---|
| Přispěvatelé: | Lewis, RUSSEL EDWARD, Verweij, Paul E. |
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
triazole-resistant Antifungal Agents Combination therapy medicine.medical_treatment Aspergillosi 030106 microbiology Triazole lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] Aspergillus fumigate Microbial Sensitivity Tests Pharmacology Aspergillosis Bioinformatics Aspergillus fumigatus invasive aspergillosi Echinocandins 03 medical and health sciences chemistry.chemical_compound Minimum inhibitory concentration Mice Drug Resistance Multiple Fungal medicine Animals Humans Antifungal Agent Immunology and Allergy In patient Animal model Echinocandin biology Animal Microbial Sensitivity Test Immunosuppression Triazoles medicine.disease biology.organism_classification Disease Models Animal Infectious Diseases chemistry Aspergillus fumigatu Human |
| Zdroj: | The Journal of Infectious Diseases, 216, suppl_3, pp. S466-s473 The Journal of Infectious Diseases, 216, S466-s473 |
| ISSN: | 0022-1899 |
| Popis: | Item does not contain fulltext Infections caused by triazole-resistant Aspergillus fumigatus are associated with a higher probability of treatment failure and mortality. Because clinical experience in managing these infections is still limited, mouse models of invasive aspergillosis fulfill a critical void for studying treatment regimens designed to overcome resistance. The type of immunosuppression, the route of infection, the timing of antifungal administration, and the end points used to assess antifungal activity affect the interpretation of data from these models. Nevertheless, these models provide important insights that help guide treatment decisions in patients with triazole-resistant invasive aspergillosis. Animal models confirmed that a high triazole minimal inhibitory concentration corresponded with triazole treatment failure and that the efficacy of other classes of drugs, such as the polyenes and echinocandins, was not affected by the presence of triazole resistance mutations. Furthermore, the feasibility of triazole dose escalation, combination therapy, and prophylaxis were explored as strategies to overcome resistance. |
| Databáze: | OpenAIRE |
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