The sex‐shift in single disease and multimorbid asthma and rhinitis during puberty:a study by MeDALL
Autor: | Keller, T, Hohmann, C, Standl, M, Wijga, A H, Gehring, U, Melén, E, Almqvist, C, Lau, S, Eller, E, Wahn, U, Christiansen, E S, von Berg, A, Heinrich, J, Lehmann, I, Maier, D, Postma, D S, Antó, J M, Bousquet, J, Keil, T, Roll, S, One Health Chemisch, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Geneeskunde van gezelschapsdieren |
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Přispěvatelé: | Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Universitat Pompeu Fabra [Barcelona] (UPF), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groningen Research Institute for Asthma and COPD (GRIAC), One Health Chemisch, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Geneeskunde van gezelschapsdieren |
Jazyk: | angličtina |
Rok vydání: | 2018 |
Předmět: |
CHILDHOOD ISAAC
Male puberty CHILDREN Disease Comorbidity Cohort Studies 0302 clinical medicine ALLERGIC DISEASES Prevalence Immunology and Allergy Sexual Maturation 030212 general & internal medicine [SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology Rhinitis Allergic/epidemiology Sexual Maturation/immunology media_common Sex Characteristics birth cohort 3. Good health PREVALENCE Natural history ADOLESCENCE Original Article Female Allergic Multimorbidity Asthma Birth Cohort Puberty Rhinitis Birth cohort medicine.medical_specialty Adolescent Immunology ECZEMA 03 medical and health sciences Young Adult AGE rhinitis medicine Journal Article media_common.cataloged_instance Humans Puberty/immunology Epidemiology and Genetics European union GENDER-DIFFERENCES [SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics business.industry NATURAL-HISTORY asthma medicine.disease Rhinitis Allergic 030228 respiratory system Family medicine Asthma/epidemiology [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ORIGINAL ARTICLES business allergic multimorbidity Work Programme |
Zdroj: | Keller, T, Hohmann, C, Standl, M, Wijga, A H, Gehring, U, Melén, E, Almqvist, C, Lau, S, Eller, E, Wahn, U, Christiansen, E S, V Berg, A, Heinrich, J, Lehmann, I, Maier, D, Postma, D S, Antó, J M, Bousquet, J, Keil, T & Roll, S 2018, ' The sex-shift in single disease and multimorbid asthma and rhinitis during puberty : a study by MeDALL ', Allergy: European Journal of Allergy and Clinical Immunology, vol. 73, no. 3, pp. 602-614 . https://doi.org/10.1111/all.13312 Allergy Allergy, Wiley, 2018, 73 (3), pp.602--614. ⟨10.1111/all.13312⟩ Allergy 73, 602-614 (2018) Recercat. Dipósit de la Recerca de Catalunya instname Allergy, 73(3), 602. Blackwell Publishing Ltd Allergy, 73(3), 602-614. Wiley-Blackwell |
ISSN: | 0105-4538 1398-9995 |
DOI: | 10.1111/all.13312 |
Popis: | Background - Cross‐sectional studies suggested that allergy prevalence in childhood is higher in boys compared to girls, but it remains unclear whether this inequality changes after puberty. We examined the sex‐specific prevalence of asthma and rhinitis as single and as multimorbid diseases before and after puberty onset in longitudinal cohort data. Methods - In six European population‐based birth cohorts of MeDALL, we assessed the outcomes: current rhinitis, current asthma, current allergic multimorbidity (ie, concurrent asthma and rhinitis), puberty status and allergic sensitization by specific serum antibodies (immunoglobulin E) against aero‐allergens. With generalized estimating equations, we analysed the effects of sex, age, puberty (yes/no) and possible confounders on the prevalence of asthma and rhinitis, and allergic multimorbidity in each cohort separately and performed individual participant data meta‐analysis. Findings - We included data from 19 013 participants from birth to age 14‐20 years. Current rhinitis only affected girls less often than boys before and after puberty onset: adjusted odds ratio for females vs males 0.79 (95%‐confidence interval 0.73‐0.86) and 0.86 (0.79‐0.94), respectively (sex‐puberty interaction P = .089). Similarly, for current asthma only, females were less often affected than boys both before and after puberty onset: 0.71, 0.63‐0.81 and 0.81, 0.64‐1.02, respectively (sex‐puberty interaction P = .327). The prevalence of allergic multimorbidity showed the strongest sex effect before puberty onset (female‐male‐OR 0.55, 0.46‐0.64) and a considerable shift towards a sex‐balanced prevalence after puberty onset (0.89, 0.74‐1.04); sex‐puberty interaction: P < .001. Interpretation - The male predominance in prevalence before puberty and the “sex‐shift” towards females after puberty onset were strongest in multimorbid patients who had asthma and rhinitis concurrently. European Union under the Health Cooperation Work Programme of the 7th Framework Programme. Grant Number: 261357 |
Databáze: | OpenAIRE |
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