The sex‐shift in single disease and multimorbid asthma and rhinitis during puberty:a study by MeDALL

Autor: Keller, T, Hohmann, C, Standl, M, Wijga, A H, Gehring, U, Melén, E, Almqvist, C, Lau, S, Eller, E, Wahn, U, Christiansen, E S, von Berg, A, Heinrich, J, Lehmann, I, Maier, D, Postma, D S, Antó, J M, Bousquet, J, Keil, T, Roll, S, One Health Chemisch, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Geneeskunde van gezelschapsdieren
Přispěvatelé: Charité - UniversitätsMedizin = Charité - University Hospital [Berlin], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Contre les MAladies Chroniques pour un VIeillissement Actif en Languedoc-Roussillon (MACVIA-LR), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Université Montpellier 1 (UM1)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Universitat Pompeu Fabra [Barcelona] (UPF), Vieillissement et Maladies chroniques : approches épidémiologique et de santé publique (VIMA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre Hospitalier Universitaire de Nîmes (CHU Nîmes)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)-European Innovation Partnership on Active and Healthy Ageing Reference Site (EIP on AHA), Commission Européenne-Commission Européenne-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Institut National de la Santé et de la Recherche Médicale (INSERM), Groningen Research Institute for Asthma and COPD (GRIAC), One Health Chemisch, dIRAS RA-2, LS IRAS EEPI ME (Milieu epidemiologie), Geneeskunde van gezelschapsdieren
Jazyk: angličtina
Rok vydání: 2018
Předmět:
CHILDHOOD ISAAC
Male
puberty
CHILDREN
Disease
Comorbidity
Cohort Studies
0302 clinical medicine
ALLERGIC DISEASES
Prevalence
Immunology and Allergy
Sexual Maturation
030212 general & internal medicine
[SDV.IMM.ALL]Life Sciences [q-bio]/Immunology/Allergology
Rhinitis
Allergic/epidemiology

Sexual Maturation/immunology
media_common
Sex Characteristics
birth cohort
3. Good health
PREVALENCE
Natural history
ADOLESCENCE
Original Article
Female
Allergic Multimorbidity
Asthma
Birth Cohort
Puberty
Rhinitis
Birth cohort
medicine.medical_specialty
Adolescent
Immunology
ECZEMA
03 medical and health sciences
Young Adult
AGE
rhinitis
medicine
Journal Article
media_common.cataloged_instance
Humans
Puberty/immunology
Epidemiology and Genetics
European union
GENDER-DIFFERENCES
[SDV.MHEP.PED]Life Sciences [q-bio]/Human health and pathology/Pediatrics
business.industry
NATURAL-HISTORY
asthma
medicine.disease
Rhinitis
Allergic

030228 respiratory system
Family medicine
Asthma/epidemiology
[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie
ORIGINAL ARTICLES
business
allergic multimorbidity
Work Programme
Zdroj: Keller, T, Hohmann, C, Standl, M, Wijga, A H, Gehring, U, Melén, E, Almqvist, C, Lau, S, Eller, E, Wahn, U, Christiansen, E S, V Berg, A, Heinrich, J, Lehmann, I, Maier, D, Postma, D S, Antó, J M, Bousquet, J, Keil, T & Roll, S 2018, ' The sex-shift in single disease and multimorbid asthma and rhinitis during puberty : a study by MeDALL ', Allergy: European Journal of Allergy and Clinical Immunology, vol. 73, no. 3, pp. 602-614 . https://doi.org/10.1111/all.13312
Allergy
Allergy, Wiley, 2018, 73 (3), pp.602--614. ⟨10.1111/all.13312⟩
Allergy 73, 602-614 (2018)
Recercat. Dipósit de la Recerca de Catalunya
instname
Allergy, 73(3), 602. Blackwell Publishing Ltd
Allergy, 73(3), 602-614. Wiley-Blackwell
ISSN: 0105-4538
1398-9995
DOI: 10.1111/all.13312
Popis: Background - Cross‐sectional studies suggested that allergy prevalence in childhood is higher in boys compared to girls, but it remains unclear whether this inequality changes after puberty. We examined the sex‐specific prevalence of asthma and rhinitis as single and as multimorbid diseases before and after puberty onset in longitudinal cohort data. Methods - In six European population‐based birth cohorts of MeDALL, we assessed the outcomes: current rhinitis, current asthma, current allergic multimorbidity (ie, concurrent asthma and rhinitis), puberty status and allergic sensitization by specific serum antibodies (immunoglobulin E) against aero‐allergens. With generalized estimating equations, we analysed the effects of sex, age, puberty (yes/no) and possible confounders on the prevalence of asthma and rhinitis, and allergic multimorbidity in each cohort separately and performed individual participant data meta‐analysis. Findings - We included data from 19 013 participants from birth to age 14‐20 years. Current rhinitis only affected girls less often than boys before and after puberty onset: adjusted odds ratio for females vs males 0.79 (95%‐confidence interval 0.73‐0.86) and 0.86 (0.79‐0.94), respectively (sex‐puberty interaction P = .089). Similarly, for current asthma only, females were less often affected than boys both before and after puberty onset: 0.71, 0.63‐0.81 and 0.81, 0.64‐1.02, respectively (sex‐puberty interaction P = .327). The prevalence of allergic multimorbidity showed the strongest sex effect before puberty onset (female‐male‐OR 0.55, 0.46‐0.64) and a considerable shift towards a sex‐balanced prevalence after puberty onset (0.89, 0.74‐1.04); sex‐puberty interaction: P < .001. Interpretation - The male predominance in prevalence before puberty and the “sex‐shift” towards females after puberty onset were strongest in multimorbid patients who had asthma and rhinitis concurrently. European Union under the Health Cooperation Work Programme of the 7th Framework Programme. Grant Number: 261357
Databáze: OpenAIRE