The role of plasma N-terminal brain natriuretic pro-peptide in diagnosing elderly patients with acute exacerbation of COPD concurrent with left heart failure
| Autor: | Ruiyun Li, Hanxiang Nie, Suping Hu, Xuhong Ding, Qianhui Chen, Shuo Chen, Nishan Deng, Ailing Wang, Xuxue Guo |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Male
China medicine.medical_specialty Exacerbation Diastole Comorbidity International Journal of Chronic Obstructive Pulmonary Disease 030204 cardiovascular system & hematology Risk Assessment Sensitivity and Specificity Hospitals University Pulmonary Disease Chronic Obstructive 03 medical and health sciences exacerbation 0302 clinical medicine Reference Values Internal medicine Natriuretic Peptide Brain medicine COPD Humans In patient Prospective Studies Geriatric Assessment Original Research Aged Aged 80 and over Heart Failure Receiver operating characteristic business.industry Left heart failure General Medicine Plasma levels Prognosis medicine.disease Echocardiography Doppler Peptide Fragments Clinical Practice Cross-Sectional Studies ROC Curve 030228 respiratory system NT-proBNP Disease Progression Cardiology Female business Biomarkers left heart failure |
| Zdroj: | International Journal of Chronic Obstructive Pulmonary Disease |
| ISSN: | 1178-2005 |
| Popis: | Xuxue Guo,1,* Hanxiang Nie,1,* Qianhui Chen,1 Shuo Chen,1 Nishan Deng,1 Ruiyun Li,1 Xuhong Ding,1 Suping Hu,1 Ailing Wang2 1Department of Respiratory Medicine, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China; 2Nursing Department, Wuhan University School of Health Sciences, Wuhan 430071, Hubei Province, China *These authors contributed equally tothis work Introduction: Acute exacerbation of COPD (AECOPD) and left heart failure (LHF) commonly exist together in clinical practice. However, the identification of AECOPD concurrent with LHF is currently challenging. Our study aimed to investigate the role of plasma N-terminal brain natriuretic pro-peptide (NT-proBNP) in diagnosing elderly patients with AECOPD associated with LHF. Methods and results: LHF was diagnosed in patients with AECOPD according to echocardiographic criteria, and the levels of NT-proBNP in plasma were measured by quantitative electrochemiluminescence assay. Among the 655 patients with AECOPD, 158 (24.1%) had comorbid LHF, whether systolic (n=108, 68.4%) or diastolic (n=50, 31.6%). The plasma concentrations of NT-proBNP in elderly patients with AECOPD associated with LHF were markedly elevated, compared with those with only AECOPD (4,542.5 and 763.0ng/L, respectively, P |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|