Relationship between Regional Fat Distribution and Hypertrophic Cardiomyopathy Phenotype

Autor: Monica D’Adamo, Paolo Preziosi, Mauro Di Roma, Leonardo Calò, Alfonso Bellia, Valeria Guglielmi, Luciano Maresca, Chiara Lanzillo, Giorgia Michela Marinoni, Paolo Sbraccia
Rok vydání: 2016
Předmět:
Male
Settore MED/09 - Medicina Interna
Magnetic Resonance Spectroscopy
Heart disease
Physiology
Cardiomyopathy
lcsh:Medicine
Blood Pressure
030204 cardiovascular system & hematology
Biochemistry
Vascular Medicine
Settore MED/13 - Endocrinologia
Muscle hypertrophy
Body Mass Index
Cohort Studies
Fats
0302 clinical medicine
Absorptiometry
Photon
Medicine and Health Sciences
Body Fat Distribution
030212 general & internal medicine
Magnetic Resonance
lcsh:Science
Multidisciplinary
Physics
Hypertrophic cardiomyopathy
Magnetism
Heart
Middle Aged
Condensed Matter Physics
Lipids
Phenotypes
medicine.anatomical_structure
Phenotype
Physiological Parameters
Hypertension
Physical Sciences
Cardiology
Female
Hypertrophy
Left Ventricular
Anatomy
Cardiomyopathies
Research Article
Adult
medicine.medical_specialty
Cardiac Ventricles
Heart Ventricles
03 medical and health sciences
Settore MED/36 - Diagnostica per Immagini e Radioterapia
Internal medicine
medicine
Genetics
Humans
Interventricular septum
Aged
Heart Failure
business.industry
lcsh:R
Body Weight
Biology and Life Sciences
Cardiomyopathy
Hypertrophic
medicine.disease
Endocrinology
Ventricle
Heart failure
Cardiovascular Anatomy
lcsh:Q
business
Body mass index
Zdroj: PLoS ONE
PLoS ONE, Vol 11, Iss 7, p e0158892 (2016)
ISSN: 1932-6203
Popis: Background Hypertrophic cardiomyopathy (HCM), the most common genetic heart disease, is characterized by heterogeneous phenotypic expression. Body mass index has been associated with LV mass and heart failure symptoms in HCM. The aim of our study was to investigate whether regional (trunk, appendicular, epicardial) fat distribution and extent could be related to hypertrophy severity and pattern in HCM. Methods Cardiovascular magnetic resonance was performed in 32 subjects with echocardiography-based diagnosis of HCM (22M/10F, 57.2±12.6 years) characterized by predominant hypertrophy at the interventricular septum (IVS). Regional fat distribution was assessed by dual-energy X-ray absorptiometry. Results Gender differences were detected in maximum IVS thickness (M: 18.3±3.8 mm vs. F: 14.3±4 mm, p = 0.012), right ventricle (RV) systolic function (M: 61.3±6.7%; F: 67.5±6.3%, p = 0.048), indexed RV end-diastolic (M: 64.8±16.3 ml/m2; F: 50.7±15.5 ml/m2, p = 0.04) and end-systolic volumes (M: 24.3±8.3 ml/m2; F: 16.7±7.4 ml/m2, p = 0.04). After adjusting for age and gender, maximum IVS thickness was associated with truncal fat (Tr-FAT) (β = 0.43, p = 0.02), but not with either appendicular or epicardial fat. Epicardial fat resulted independently associated with NT-proBNP levels (β = 0.63, p = 0.04). Late Gadolinium Enhancement-positive subjects displayed greater maximum IVS thickness (p = 0.02), LV mass index (p = 0.015) and NT-proBNP levels (p = 0.04), but no associations with fat amount or distribution were observed. Conclusion Truncal, but not appendicular or epicardial fat amount, seems to be related with maximum IVS thickness, the hallmark feature in our cohort of HCM patients. Further prospective researches are needed to assess a potential causative effect of central adiposity on HCM phenotype.
Databáze: OpenAIRE
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