Evaluation of the use of raw extract of Euphorbia tirucalli L. in the healing process of skin wounds in mice
| Autor: | Allan Kardec Duailibe Barros Filho, Orlando José dos Santos, Rafael Campos Silva, Rennan Abud Pinheiro Santos, Euler Nicolau Sauaia Filho, Rayan Haquim Pinheiro Santos, Altieres de Arruda Rocha |
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| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
Male
medicine.medical_specialty Pathology Time Factors Skin wound RD1-811 Euphorbia tirucalli medicine.medical_treatment Gastroenterology Resection Lesion Random Allocation Mice Fibrosis Euphorbia Internal medicine Animals Medicine Saline Skin Inflammation Wound Healing biology Plant Extracts business.industry Significant difference Fibroblasts biology.organism_classification medicine.disease Histopathology Surgery medicine.symptom business Phytotherapy |
| Zdroj: | Acta Cirúrgica Brasileira v.28 n.10 2013 Acta Cirúrgica Brasileira Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia (SBDPC) instacron:SBDPC Acta Cirurgica Brasileira, Vol 28, Iss 10, Pp 716-720 (2013) Acta Cirurgica Brasileira, Volume: 28, Issue: 10, Pages: 716-720, Published: OCT 2013 |
| Popis: | PURPOSE: To evaluate the effects of crude extract of Euphorbia tirucalli in cutaneous wound healing. METHODS: A total of 20 Swiss mice were randomly divided into two groups, aveloz (GA) and control (CG), and each group was further divided into two subgroups based on the deaths scheduled for the 7th and 14th days after surgery. The animals underwent a resection of cutaneous fragment with 1cm in diameter on the dorsum; the GA was applied in each animal on the subsequent days, 0.1 mL (30 mg/mL) hydroalcoholic extract of Euphorbia tirucalli was applied on the wound, while the same volume of 0.9% saline solution was applied to the GC. It was evaluated the lesion diameter and after programmed death, a surgical specimen was resected for histopathology. RESULTS: In the macroscopic analysis, no statistically significant difference was observed (p = 0.120 and p = 0.186, for the 7th and 14th days of death, respectively). The histological evaluation revealed no statistically significant difference in the variables acute inflammation (p = 0.014) and fibrosis (p = 0.018), when compared the group aveloz with the control group on day 14. CONCLUSION: The crude hydroalcoholic extract of Euphorbia tirucalli L. demonstrated better outcomes in the healing process, acute inflammation and fibrosis on the 14 day postoperatively. |
| Databáze: | OpenAIRE |
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