Short-circuiting autoimmune disease by target-tissue-derived nitric oxide
| Autor: | Yvonne R Garcia, Keith A. Krolick |
|---|---|
| Rok vydání: | 2004 |
| Předmět: |
medicine.medical_specialty
Programmed cell death Immunology Nitric Oxide Synthase Type II Apoptosis Receptors Nicotinic Nitric Oxide Nitric oxide Autoimmune Diseases chemistry.chemical_compound Internal medicine medicine Immunology and Allergy Animals Receptor Acetylcholine receptor Autoimmune disease biology Macrophages Muscles Antibodies Monoclonal medicine.disease Myasthenia gravis Rats Nitric oxide synthase Endocrinology chemistry biology.protein Female Nitric Oxide Synthase |
| Zdroj: | Clinical immunology (Orlando, Fla.). 113(1) |
| ISSN: | 1521-6616 |
| Popis: | A previous report from this laboratory suggested that expression of skeletal-muscle-derived, inducible nitric oxide synthase (iNOS), is associated with resistance to the autoimmune model of myasthenia gravis (MG) demonstrated by Wistar Furth rats following the passive transfer of antibody reactive with the nicotinic acetylcholine receptor (AChR). The study reported below demonstrates an association between increased expression of iNOS/NO in Wistar Furth rats and the induction of programmed cell death (apoptosis) in both macrophages and CD4+ T cells that attempt to traffic through targeted muscles. It is concluded that production of muscle-derived NO is protective in experimental MG, and in part, dictates the severity of eventual immunopathology. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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