Electrospun hypromellose-based hydrophilic composites for rapid dissolution of poorly water-soluble drug
Autor: | Deng Yangchao, Xin-Kuan Liu, Ling-Ling Zhang, Wang Qing, Deng-Guang Yu, Min Zhao |
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Rok vydání: | 2017 |
Předmět: |
Materials science
Coumaric Acids Polymers and Plastics 02 engineering and technology Polyethylene glycol 010402 general chemistry behavioral disciplines and activities 01 natural sciences Polyvinyl alcohol Polyethylene Glycols Taylor cone chemistry.chemical_compound Hypromellose Derivatives mental disorders Materials Chemistry Dissolution testing Composite material Dissolution Drug Carriers Organic Chemistry technology industry and agriculture Water 021001 nanoscience & nanotechnology Casting 0104 chemical sciences Volumetric flow rate Solubility chemistry embryonic structures sense organs 0210 nano-technology Drug carrier Hydrophobic and Hydrophilic Interactions |
Zdroj: | Carbohydrate Polymers. 174:617-625 |
ISSN: | 0144-8617 |
Popis: | Hypromellose (HPMC)-based hydrophilic composites (HCs) used for rapid dissolution of ferulic acid (FA) were investigated. Electrospun and casting HCs were prepared from a solution containing HPMC, FA, and polyethylene glycol. Ethanol was used as sheath fluid during coaxial processes, and the effects of its flow rates on the Taylor cone and straight fluid jet were investigated. The morphology, component state, hydrophilicity, and drug dissolution rate of the HCs were characterized. Results demonstrated that all HCs were amorphous materials, and their components were compatible. However, the dissolution rate of electrospun HCs was 10 times faster than that of casting HCs. The smaller the diameters of electrospun HCs were, the better their performances were. The mechanism of electrospun HCs was suggested. By utilizing modified coaxial electrospinning and combinations of drug carriers, new types of HPMC-based HCs can provide an alternative approach for the effective delivery of poorly water-soluble drugs. |
Databáze: | OpenAIRE |
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