Calcium signaling mediates the response to cadmium toxicity in Saccharomyces cerevisiae cells
| Autor: | Andrei Florin Danet, Ileana C. Farcasanu, Valentina C. Popa, Lavinia L. Ruta, Ioana Nicolau, Virgil Iordache, Aurora Neagoe |
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| Rok vydání: | 2014 |
| Předmět: |
inorganic chemicals
Saccharomyces cerevisiae Proteins Saccharomyces cerevisiae Biophysics Aequorin chemistry.chemical_element Biology Biochemistry Cytosol Copper Transport Proteins Structural Biology Iron-Binding Proteins Genetics Homeostasis Calcium Signaling Heavy metal stress Cation Transport Proteins Molecular Biology Calcium signaling Cadmium Dose-Response Relationship Drug Endoplasmic reticulum Cell Membrane Biological Transport Cell Biology biology.organism_classification Molecular biology Yeast Oxidative Stress chemistry Mutation biology.protein Calcium Environmental Pollutants Transcription Factors |
| Zdroj: | FEBS Letters. 588:3202-3212 |
| ISSN: | 1873-3468 0014-5793 |
| Popis: | The involvement of Ca(2+) in the response to high Mn(2+), Co(2+), Ni(2+), Cu(2+), Zn(2+), Cd(2+), and Hg(2+) was investigated in Saccharomyces cerevisiae. The yeast cells responded through a sharp increase in cytosolic Ca(2+) when exposed to Cd(2+), and to a lesser extent to Cu(2+), but not to Mn(2+), Co(2+), Ni(2+), Zn(2+), or Hg(2+). The response to high Cd(2+) depended mainly on external Ca(2+) (transported through the Cch1p/Mid1p channel) but also on vacuolar Ca(2+) (released into the cytosol through the Yvc1p channel). The adaptation to high Cd(2+) was influenced by perturbations in Ca(2+) homeostasis. Thus, the tolerance to Cd(2+) often correlated with sharp Cd(2+)-induced cytosolic Ca(2+) pulses, while the Cd(2+) sensitivity was accompanied by the incapacity to rapidly restore the low cytosolic Ca(2+). |
| Databáze: | OpenAIRE |
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