Evaluation of Antibody Response to Polysaccharide Vaccine and Switched Memory B Cells in Pediatric Patients with Inflammatory Bowel Disease
| Autor: | Habib Soheili, Nima Parvaneh, Gholamhossein Fallahi, Asghar Aghamohammadi, Mehri Najafi, Nima Rezaei, Hossein Asgarian-Omran, Payam Mohammadinejad, Khadije Soleimani, Behzad Darabi, Mojtaba Hashemi, Shabnam Pourhamdi, Rasoul Nasiri Kalmarzi, Fatemeh Farhmand, Hassan Abolhassani, Ahmad Khodadad, Babak Mirminachi, Farzaneh Motamed |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Adolescent Polysaccharide vaccine Inflammatory bowel diseases Polysaccharide Vaccine Gastroenterology Inflammatory bowel disease Colitis ulcerative Pneumococcal Vaccines Immune system Polysaccharides Internal medicine medicine Humans Colitis Child B cell B-Lymphocytes Gastrointestinal tract Alimentary Tract Hepatology business.industry Crohn disease medicine.disease digestive system diseases Treatment Outcome Antibody response medicine.anatomical_structure Child Preschool Immunoglobulin G Antibody Formation Immunology Etiology Original Article Female Switched memory B cells business |
| Zdroj: | Gut and Liver |
| ISSN: | 2005-1212 1976-2283 |
| DOI: | 10.5009/gnl.2014.8.1.24 |
| Popis: | Background/Aims Inflammatory bowel disease (IBD) is a chronic disease of the gastrointestinal tract, whose etiologies are still unknown. This study was performed to evaluate the humoral immune response in terms of B cell functions in selected IBD patients. Methods Eighteen pediatric patients with IBD, including 12 cases of ulcerative colitis (UC) and six with Crohn disease (CD), were enrolled in this study. The pneumococcal vaccine was injected in all patients, and the IgG antibody level to the polysaccharide antigen was measured before and 4 weeks after injection. The B cell switch-recombination process was evaluated. Results Five patients with IBD (three CD and two UC) had defects in B cell switching, which was significantly higher than in controls (p=0.05). Ten patients had a specific antibody deficiency and exhibited a higher frequency of bacterial infection than the healthy group. The mean increased level of IgG after vaccination was lower in IBD patients (82.9±32.5 µg/mL vs 219.8±59.0 µg/mL; p=0.001). Among the patients who had an insufficient response, no significant difference in the number of switched memory B-cell was observed. Conclusions A defect in B lymphocyte switching was observed in pediatric IBD patients, and especially in those patients with CD. Owing to an increased risk of bacterial infections in those patients with antibody production defects, pneumococcal vaccination could be recommended. However, not all patients can benefit from the vaccination, and several may require other prophylactic methods. |
| Databáze: | OpenAIRE |
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