Approaches for the vaccination and treatment of Neospora caninum infections in mice and ruminant models
| Autor: | Andrew Hemphill, Adriana Aguado-Martínez, Joachim Müller |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Protozoan Vaccines Cattle Diseases Sheep Diseases 03 medical and health sciences Mice Neospora medicine Animals Sheep biology 630 Agriculture Transmission (medicine) Coccidiosis Vaccination medicine.disease biology.organism_classification Virology Neospora caninum Infectious Disease Transmission Vertical 3. Good health Chronic infection Disease Models Animal 030104 developmental biology Infectious Diseases Drug development Immunology Animal Science and Zoology Parasitology Cattle Anti-Infective Agents |
| Zdroj: | Parasitology Hemphill, Andrew; Aguado Martinez, Adriana; Müller, Joachim (2016). Approaches for the vaccination and treatment of Neospora caninum infections in mice and ruminant models. Parasitology, 143(3), pp. 245-259. Cambridge University Press 10.1017/S0031182015001596 |
| DOI: | 10.1017/S0031182015001596 |
| Popis: | SUMMARYNeospora caninumis a leading cause of abortion in cattle, and is thus an important veterinary health problem of high economic significance. Vaccination has been considered a viable strategy to prevent bovine neosporosis. Different approaches have been investigated, and to date the most promising results have been achieved with live-attenuated vaccines. Subunit vaccines have also been studied, and most of them represented components that are functionally involved in (i) the physical interaction between the parasite and its host cell during invasion or (ii) tachyzoite-to-bradyzoite stage conversion. Drugs have been considered as an option to limit the effects of vertical transmission ofN. caninum.Promising results with a small panel of compounds in small laboratory animal models indicate the potential value of a chemotherapeutical approach for the prevention of neosporosis in ruminants. For both, vaccines and drugs, the key for success in preventing vertical transmission lies in the application of bioactive compounds that limit parasite proliferation and dissemination, without endangering the developing fetus not only during an exogenous acute infection but also during recrudescence of a chronic infection. In this review, the current status of vaccine and drug development is presented and novel strategies against neosporosis are discussed. |
| Databáze: | OpenAIRE |
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