Lipid-Lowering Therapy is Related to Inflammatory Markers and 3-Year Mortality in Patients With Critical Limb Ischemia
| Autor: | Jamal Barani, Anders Gottsäter, Ingrid Mattiasson, Nazim Isma, Bengt Lindblad |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Male
medicine.medical_specialty Statin medicine.drug_class Ischemia Alpha (ethology) Hyperlipidemias Inflammation Gastroenterology chemistry.chemical_compound Sex Factors Internal medicine medicine Humans Aged Hypolipidemic Agents Interleukin-6 Tumor Necrosis Factor-alpha Cholesterol business.industry Cholesterol HDL Age Factors Neopterin Cholesterol LDL Critical limb ischemia medicine.disease Surgery C-Reactive Protein Logistic Models chemistry Female lipids (amino acids peptides and proteins) Tumor necrosis factor alpha medicine.symptom Cardiology and Cardiovascular Medicine business Biomarkers |
| Zdroj: | Angiology. 59:542-548 |
| ISSN: | 1940-1574 0003-3197 |
| DOI: | 10.1177/0003319707306144 |
| Popis: | To evaluate relationships between lipid-lowering therapy, inflammation, and 3-year mortality in critical limb ischemia (CLI), 259 consecutive CLI patients underwent evaluation of medication, tumor necrosis factor-α, interleukin-6 (IL-6), neopterin, high-sensitivity C-reactive protein (hs-CRP), 8-epi-PGF2 α, and endothelin-1. Mortality was assessed after 3 years. Sixty-one patients (24%) were on lipid-lowering therapy and 59 patients (97%) on statins. Patients on lipid-lowering therapy were younger and showed lower low-density lipoprotein cholesterol, hs-CRP, and IL-6 levels than patients without therapy. Three-year survival was higher among patients on lipid-lowering therapy. In logistic regression, the effect of lipid-lowering therapy on 3-year survival was significant with inflammatory markers entered into the model one by one but disappeared when all inflammatory markers were entered into the model together. In conclusion, hs-CRP and IL-6 levels were lower and 3-year survival was higher in CLI patients on lipid-lowering therapy. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|