Cytomegalovirus Infection and Pre-Eclampsia
Autor: | Nina Şincu, Adina Huţanu, Rozalia Gabor, Carmen Rădulescu |
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Rok vydání: | 2016 |
Předmět: |
medicine.medical_specialty
immunoglobulin g (igg) 030219 obstetrics & reproductive medicine Eclampsia enzyme linked immunosorbent assay (elisa) business.industry cytomegalovirus infection (cmv) medicine.disease female genital diseases and pregnancy complications Cytomegalovirus infection 03 medical and health sciences 0302 clinical medicine pre-eclampsia (pe) Internal medicine embryonic structures medicine Medicine 030212 general & internal medicine General Pharmacology Toxicology and Pharmaceutics business General Dentistry reproductive and urinary physiology interleukine (il) |
Zdroj: | Acta Medica Marisiensis, Vol 62, Iss 2, Pp 280-284 (2016) |
ISSN: | 2247-6113 |
Popis: | Introduction: Pre-eclampsia is a pregnancy-specific disease characterized by hypertension after 20 weeks of gestation and proteinuria. It is a major cause of maternal and perinatal morbidity and mortality. The pathogenesis of pre-eclampsia is not completely understood. In our study we investigated if there is a potential link between cytomegalovirus infection and pre-eclampsia and if cytomegalovirus infection is the triggering factor of pre-eclampsia. Material and methods: This study was carried out in a secondary care hospital between January 2014 and July 2015. We included two groups of pregnant women: 66 with pre-eclampsia and 62 without pre-eclampsia. Enzyme linked immunosorbent assay (ELISA) technique was performed to detect cytomegalovirus Immunoglobulin G levels in maternal serum. Results: The p-value between median values of positive cytomegalovirus IgG in pre-eclamptic women and in controls was not significant (p:0.867). Odds ratio for cytomegalovirus IgG in pre-eclamptic group (OR:0.967; 95%CI:0.535-1.748) do not differ greatly from the value recorded in the control group (OR:1.036; 95%CI:0.571-1.880). The risk for preterm birth in pre-eclamptic women with cytomegalovirus IgG positive values (OR:1.009; 95%CI:0.329-3.090) was greater than those which had term delivery (OR:0.994; 95%CI:0.472-2.095) but the two values are not very high. We found a positive correlation coefficient (0.217) at a “p” value of 0.08 between white blood cells, but a negative correlation coefficient between the percentage of neutrophils and cytomegalovirus infection. Conclusion: Cytomegalovirus infection may be associated with pre-eclampsia but it is unlikely to be the triggering factor of pre-eclampsia. |
Databáze: | OpenAIRE |
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