Ontogeny of Small Intestinal Glutaminase and Glutamine Synthetase in the Rat: Response to Dexamethasone
| Autor: | Vivek Shenoy, Pierre Musy, Josef Neu, Gaines Martin, William H. Meetze |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Ontogeny Gestational Age Biology Dexamethasone Rats Sprague-Dawley Fetus Glutaminase Glutamate-Ammonia Ligase Pregnancy Internal medicine Glutamine synthetase Intestine Small Gene expression medicine Animals RNA Messenger Maternal-Fetal Exchange Blotting Northern Small intestine Animals Suckling Rats Glutamine Endocrinology medicine.anatomical_structure Animals Newborn Pediatrics Perinatology and Child Health Female Developmental Biology medicine.drug |
| Zdroj: | Neonatology. 64:368-375 |
| ISSN: | 1661-7819 1661-7800 |
| DOI: | 10.1159/000244013 |
| Popis: | The ontogeny of small intestinal glutaminase (GA) and glutamine synthetase (GS) was studied with relation to the maternal administration of dexamethasone (DEX). Pregnant Sprague-Dawley rats were administered 0.2 mg/kg of DEX or saline twice daily on days 19 and 20 of gestation. Activity of GA did not increase from the fetus to the 10-day-old rat; however, GS activity increased 7-fold. DEX induced doubling of GA activity and mRNA, but only a slight increase is GS activity and mRNA was observed in the fetus. GA and GS activities appear to be regulated by different mechanisms. |
| Databáze: | OpenAIRE |
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