Unmodified, autologous adipose-derived regenerative cells improve cardiac function, structure and revascularization in a porcine model of chronic myocardial infarction
| Autor: | Claudia Kettlun, Tahereh Karimi, Amish S. Dave, Miguel Valderrábano, Dipan J. Shah, Alon Azares, Alexander Haenel, Eckhard Alt, Jody Vykoukal, Daryl G. Schulz, Mohamad G. Ghosn, Albert E. Raizner |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
Cardiac function curve
medicine.medical_specialty Ejection fraction business.industry medicine.medical_treatment Adipose-Derived Regenerative Cells medicine.disease Revascularization medicine.anatomical_structure Internal medicine medicine Cardiology cardiovascular system Myocardial infarction Vein business Saline Artery |
| DOI: | 10.1101/286468 |
| Popis: | Numerous studies have investigated cell-based therapies for myocardial infarction (MI), with mixed results. In the present study the left anterior descending (LAD) artery of pigs was occluded for 180 min. Four weeks later, the mean left ventricular ejection fraction (LVEF) was shown to have been reduced to approximately 35%. At that time, 18×106 unmodified, autologous adipose-derived regenerative cells (UA-ADRCs) were delivered into the LAD vein (control: delivery of saline). Six weeks following UA-ADRCs/saline delivery, the mean LVEF had increased by 18% (p |
| Databáze: | OpenAIRE |
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