Leptin modulates oocyte maturation by a central and a direct pathway in zebrafish

Autor:	Amrutha Bagivalu Lakshminarasimha, Madhuri Puvvada, Matthias Hammerschmidt, Maximilian Michel
Rok vydání:	2022
Předmět:	Leptin Mammals endocrine system Endocrinology Endocrinology Diabetes and Metabolism Oocytes Animals Zebrafish
Zdroj:	Journal of Endocrinology. 254:1-12
ISSN:	1479-6805 0022-0795
DOI:	10.1530/joe-22-0026
Popis:	Loss of LEPR function (LOF) in mammals leads to diverse phenotypes including morbid obesity and infertility while zebrafish show relatively minor phenotypes. This however allows the study of LEPR LOF in the absence of the detrimental effects of hyperglycemia or obesity. Here, we show evidence that leptin plays a role in the central as well as peripheral regulation of the hypothalamic–pituitary–gonadal (HPG) axis in zebrafish. Animals with a Lepr LOF show dysregulated pituitary HPG genes as well as evidence that oocytes mature slower and/or exhibit an increased rate of atresia. In culture, Lepr LOF attenuates the effect of 17α-20β-dihydroxy-4 pregnen-3-one in promoting germinal vesicle breakdown (GVBD) and increases the rate of GVBD as well as attenuates the rate of oocyte atresia.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a42685642586eb35962e2282936507c https://doi.org/10.1530/joe-22-0026 Zobrazit plný text záznamu