Severity assessment and scoring for neurosurgical models in rodents
| Autor: | Katrin Becker, Ute Lindauer, Sarah Pinkernell |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Research design medicine.medical_specialty Subarachnoid hemorrhage Traumatic brain injury Behavioral testing Neurosurgery 03 medical and health sciences Severity assessment Mice 0302 clinical medicine Stress Physiological Brain Injuries Traumatic Medicine Animals Pain Measurement Stress assessment Analgesics Pain Postoperative General Veterinary business.industry Sequela Subarachnoid Hemorrhage medicine.disease Rats Disease Models Animal 030104 developmental biology Research Design Anesthesia Animal Science and Zoology business 030217 neurology & neurosurgery |
| Zdroj: | Laboratory animals. 50(6) |
| ISSN: | 1758-1117 |
| Popis: | The most important acute neurological diseases seen at neurosurgery departments are traumatic brain injuries (TBI) and subarachnoid hemorrhages (SAH). In both diseases the pathophysiological sequela are complex and have not been fully understood up to now, and rodent models using rats and mice are most suitable for the investigation of the pathophysiological details. In both models, surgery is performed under anesthesia, followed by assessment of their functional outcome and behavioral testing before brain tissue analysis after euthanasia. Postoperative analgesia is mandatory, and supplementary care is highly recommended for refinement purposes. Pain and stress assessment is mainly based on clinical and behavioral signs, and further research is needed to improve the evaluation of severity in these models. |
| Databáze: | OpenAIRE |
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