Steamed Ginger May Enhance Insulin Secretion through KATP Channel Closure in Pancreatic β-Cells Potentially by Increasing 1-Dehydro-6-Gingerdione Content
| Autor: | Se Chan Kang, Youn Hee Nam, Young Tae Koo, Yeong-Geun Lee, Dong-Hyun Paik, Tamanna Yasmin, Ji Heon Shim, Hyelin Jeon, Min Seon Park, Seo Yule Jeong, Isabel Rodriguez, Nam-In Baek, Tong Ho Kang, Bin Na Hong, Sang Hun Lee, Na Woo Kim, Yong Joon Jeong |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
mice Ginger Extract lcsh:TX341-641 Pharmacology steamed ginger extract 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Therapeutic index Diabetes mellitus Alloxan medicine KATP channels katp channels Nutrition and Dietetics pancreatic islets Pancreatic islets medicine.disease zebrafish 030104 developmental biology medicine.anatomical_structure Mechanism of action chemistry 1-dehydro-6-gingerdione 030220 oncology & carcinogenesis Toxicity diabetes mellitus Zingiber officinale medicine.symptom lcsh:Nutrition. Foods and food supply Food Science |
| Zdroj: | Nutrients, Vol 12, Iss 2, p 324 (2020) Nutrients Volume 12 Issue 2 |
| ISSN: | 2072-6643 |
| Popis: | Ginger (Zingiber officinale Roscoe) and its active compounds (gingerols, shogaols and paradols) have been reported as having beneficial functions for several diseases, including diabetes. In this study, we revealed that the steaming process could enhance the anti-diabetic potential of ginger. To confirm the anti-diabetic effect of steamed ginger extract (GG03), we assessed pancreatic islets impaired by alloxan in zebrafish and demonstrated anti-hyperglycemic efficacy in a mouse model. The EC50 values of ginger extract (GE) and GG03 showed that the efficacy of GG03 was greater than that of GE. In addition, LC50 values demonstrated that GG03 had lower toxicity than GE, and the comparison of the Therapeutic Index (TI) proved that GG03 is a safer functional food. Furthermore, our data showed that GG03 significantly lowered hyperglycemia in a diabetic mouse model. HPLC was performed to confirm the change in the composition of steamed ginger. Interestingly, GG03 showed a 375% increase in 1-dehydro-6-gingerdione (GD) compared with GE. GD has not yet been studied much pharmacologically. Thus, we identified the protective effects of GD in the damaged pancreatic islets of diabetic zebrafish. We further assessed whether the anti-diabetic mechanism of action of GG03 and GD involves insulin secretion. Our results suggest that GG03 and GD might stimulate insulin secretion by the closure of KATP channels in pancreatic &beta cells. |
| Databáze: | OpenAIRE |
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