Activin signaling and its role in regulation of cell proliferation, apoptosis, and carcinogenesis
| Autor: | Ye-Guang, Chen, Qiang, Wang, Shi-Lung, Lin, C Donald, Chang, Jody, Chuang, Jody, Chung, Shao-Yao, Ying |
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| Rok vydání: | 2006 |
| Předmět: |
0301 basic medicine
Programmed cell death Follistatin Activin Receptors Apoptosis Smad2 Protein Biology General Biochemistry Genetics and Molecular Biology 03 medical and health sciences 0302 clinical medicine Neoplasms TGF beta signaling pathway Humans Smad3 Protein Activin type 2 receptors Cell Proliferation Cell growth Cell Differentiation Activin receptor Cell biology Activins 030104 developmental biology 030220 oncology & carcinogenesis Cancer research Signal transduction ACVR2B Transforming growth factor Signal Transduction |
| Zdroj: | Experimental biology and medicine (Maywood, N.J.). 231(5) |
| ISSN: | 1535-3702 |
| Popis: | Activins, cytokine members of the transforming growth factor-β superfamily, have various effects on many physiological processes, including cell proliferation, cell death, metabolism, homeostasis, differentiation, immune responses endocrine function, etc. Activins interact with two structurally related serine/threonine kinase receptors, type I and type II, and initiate downstream signaling via Smads to regulate gene expression. Understanding how activin signaling is controlled extracellularly and intracellularly would not only lead to more complete understanding of cell growth and apoptosis, but would also provide the basis for therapeutic strategies to treat cancer and other related diseases. This review focuses on the recent progress on activin-receptor interactions, regulations of activin signaling by ligand-binding proteins, receptor-binding proteins, and nucleocytoplasmic shuttling of Smad proteins. |
| Databáze: | OpenAIRE |
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