Outcomes of COVID-19 in Patients with Cirrhosis or Liver Transplantation

Autor: Narendra S. Choudhary, Neeraj Saraf, Swapnil Dhampalwar, Arvinder S. Soin
Rok vydání: 2021
Předmět:
NAFLD
non-alcoholic fatty liver disease
medicine.medical_specialty
ACLF
acute-on chronic liver failure
Cirrhosis
Coronavirus disease 2019 (COVID-19)
liver diseases
ALT
alanine transaminase
NASH
non-alcoholic steatohepatitis
medicine.medical_treatment
LFT
liver function tests
Review Article
AST
aspartate aminotransferase
Liver transplantation
LT
liver transplantation
Chronic liver disease
SARS-CoV-2
severe acute respiratory syndrome coronavirus 2
Gastroenterology
MELD
model for end-stage liver disease
03 medical and health sciences
0302 clinical medicine
HCWs
health care workers
Internal medicine
medicine
Risk of mortality
ALI
acute liver injury
In patient
COVID-19
Coronavirus disease 2019
immunosuppression
Hepatology
SARS-CoV-2
business.industry
NASH
ACE
angiotensin converting enzyme related carboxypeptidase receptors
Immunosuppression
medicine.disease
Decompensated cirrhosis
mortality
HR
hazard ratio
030220 oncology & carcinogenesis
CLD
chronic liver disease
030211 gastroenterology & hepatology
business
OR
Odds ratio
Zdroj: Journal of Clinical and Experimental Hepatology
ISSN: 0973-6883
DOI: 10.1016/j.jceh.2021.05.003
Popis: Coronavirus disease 2019 (COVID-19) is associated with a significant morbidity and mortality in patients with cirrhosis. There is a significantly higher morbidity and mortality due to COVID-19 in patients with decompensated cirrhosis as compared to compensated cirrhosis, and in patients with cirrhosis as compared to non-cirrhotic chronic liver disease. The fear of COVID-19 before or after liver transplantation has lead to a significant reduction in liver transplantation numbers, and patients with decompensated cirrhosis remain at risk of wait list mortality. The studies in liver transplantation recipients show that risk of mortality due to COVID-19 is generally driven by higher age and comorbidities. The current review discusses available literature regarding outcomes of COVID-19 in patients with cirrhosis and outcomes in liver transplant recipients.
Databáze: OpenAIRE
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