Multimodal iron oxide (Fe3O4)-saturated lactoferrin nanocapsules as nanotheranostics for real-time imaging and breast cancer therapy of claudin-low, triple-negative (ER-/PR-/HER2-)
| Autor: | Sishir K Kamalapuram, Rupinder K. Kanwar, Jagat R. Kanwar, Subramanian Krishnakumar |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Materials science Biocompatibility Biomedical Engineering Medicine (miscellaneous) Triple Negative Breast Neoplasms Bioengineering 02 engineering and technology Development Inhibitor of apoptosis Ferric Compounds Theranostic Nanomedicine Nanocapsules 03 medical and health sciences Breast cancer mental disorders Survivin medicine Humans General Materials Science biology Lactoferrin 021001 nanoscience & nanotechnology medicine.disease Claudin-Low 030104 developmental biology Claudins Immunology Cancer research biology.protein Female 0210 nano-technology |
| Zdroj: | Nanomedicine. 11:249-268 |
| ISSN: | 1748-6963 1743-5889 |
| DOI: | 10.2217/nnm.15.199 |
| Popis: | Aim: To unravel the multimodal nanotheranostic ability of Fe3O4-saturated bovine lactoferrin nanocapsules (FebLf NCs) in claudin-low, triple-negative breast cancer model. Materials & methods: Xenograft study was performed to examine biocompatibility, antitumor efficacy and multimodal nanotheranostic action in combination with near-infrared live mice imaging. Results: FebLf NCs exhibited a size range of 80 nm ± 5 nm with observed superparamagnetism. FebLf NCs successfully internalized into breast cancer cells through receptor-mediated endocytosis and induced apoptosis through the downregulation of inhibitor of apoptosis survivin and livin proteins. Investigations revealed a remarkable biocompatibility, anticancer efficacy of the FebLf NCs. Near-infrared imaging observations confirmed selective localization of multimodal FebLf NCs at the tumor site and lead to time-dependent reduction of tumor growth. Conclusion: FebLf NCs can be safe, biocompatible nanotheranostic approach for real-time imaging and monitoring the effect of drugs in real time and have potentials in future clinical trials. |
| Databáze: | OpenAIRE |
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