Preeclampsia Is Associated With Increased Preclinical Carotid Atherosclerosis in Women With Type 1 Diabetes
| Autor: | Irene Vinagre, Maite Valverde, Marga Giménez, Eva López, Adriana Pané, Laura Codina, Carmen Quirós, Xavier Urquizu, Antonio J. Amor, Eva Meler, Maria J. Barahona, Ignacio Conget, Verónica Perea |
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| Rok vydání: | 2019 |
| Předmět: |
Adult
Carotid Artery Diseases endocrine system medicine.medical_specialty endocrine system diseases Endocrinology Diabetes and Metabolism Clinical Biochemistry Population 030209 endocrinology & metabolism 030204 cardiovascular system & hematology Carotid Intima-Media Thickness Biochemistry Gastroenterology Preeclampsia 03 medical and health sciences 0302 clinical medicine Endocrinology Pre-Eclampsia Pregnancy Risk Factors immune system diseases Internal medicine medicine Humans Risk factor education Type 1 diabetes education.field_of_study business.industry Biochemistry (medical) nutritional and metabolic diseases Odds ratio Middle Aged Prognosis medicine.disease Confidence interval Cross-Sectional Studies Diabetes Mellitus Type 1 Case-Control Studies Female business Biomarkers Follow-Up Studies Retinopathy |
| Zdroj: | The Journal of Clinical Endocrinology & Metabolism. 105:85-95 |
| ISSN: | 1945-7197 0021-972X |
| Popis: | Purpose Although preeclampsia (PE) is a well-established cardiovascular risk factor (CVRF) in the general population, its role in type 1 diabetes (T1D) has been scarcely studied. We assessed the association between PE and preclinical atherosclerosis in T1D. Methods We recruited 112 women without cardiovascular disease and last pregnancy ≥5 years before: (1) T1D and previous PE (T1D+/PE+; n = 28); (2) T1D without preeclampsia (T1D+/PE–; n = 28); (3) previous PE without T1D (T1D–/PE+; n = 28); and (4) controls (without T1D or PE; T1D–/PE–; n = 28). Groups were matched by age, several CVRFs, and diabetes duration and retinopathy (in T1D participants). Carotid intima-media thickness (IMT) and the presence of plaque (IMT ≥ 1.5 mm) were assessed by standardized ultrasonography protocol. Results Mean age of the participants was 44.9 ± 7.8 years (14.3% hypertension and 21.4% active smokers). Groups including T1D (T1D+/PE+ and T1D+/PE–) more frequently presented hypertension and statin treatment (23.2% vs 5.4% and 37.5% vs 8.9%; respectively; P < 0.01), without differences in other CVRFs. Carotid plaques were observed in 20.5%. In multivariate models adjusted for age, CVRF, and statins, both T1D and PE showed a similar impact on the presence of plaque, with odds ratios (95% confidence interval), 5.45 (1.36–21.9) and 4.24 (1.04–17.3), respectively. Both entities showed an additive effect when combined, both in common carotid-IMT (T1D+/PE– or T1D–/PE+, β = 0.198; T1D+/PE+, β = 0.297) and in the presence of plaque (8.53 [1.07–68.2] and 28.1 [2.67–296.4], respectively). Conclusions Previous PE was independently associated with preclinical atherosclerosis in T1D. Further studies are needed to ascertain its usefulness for stratifying risk in T1D women. |
| Databáze: | OpenAIRE |
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