Outcomes of Measurable Residual Disease in Pediatric Acute Myeloid Leukemia before and after Hematopoietic Stem Cell Transplant: Validation of Difference from Normal Flow Cytometry with Chimerism Studies and Wilms Tumor 1 Gene Expression

Autor:	Alexia Adams, Sanjay P Ahuja, Alfred P. Gillio, Roberta H. Adams, Lisa Eidenschink Brodersen, Sureyya Savasan, Mingwei Fei, Michael R. Loken, Michael A. Pulsipher, Kwang Woo Ahn, Morris Kletzel, David A. Jacobsohn, Pierre Teira, Barbara Bambach, Jeffrey H. Davis, David C. Delgado, Ann E. Haight, Reggie E. Duerst, Allen R. Chen, Mehmet Ozkaynak, Christopher C. Dvorak, Kimberly A. Kasow, Soheil Meshinchi, Troy C. Quigg, Madhu Gowda, Brent R. Logan, Julie-An Talano, Kirk R. Schultz, Victor Lewis, Bronwen E. Shaw, Michael Boyer, David Mitchell, David M. Loeb, Albert Kheradpour, Andrew C. Harris, Hilary Haines, Eneida R. Nemecek, Amy K. Keating, Shalini Shenoy, Robert J. Greiner, Aleksandra Petrovic, Marie Olszewski, Paul L. Martin, Terry J. Fry, Michelle Hudspeth, Alexandra Cheerva, Sana Khan, Monica Bhatia, Steven P. Margossian
Rok vydání:	2018
Předmět:	Myeloid Male Oncology Cytogenetics and molecular genetics Neoplasm Residual Transplantation Conditioning medicine.medical_treatment Disease Hematopoietic stem cell transplantation Regenerative Medicine 0302 clinical medicine Stem Cell Research - Nonembryonic - Human hemic and lymphatic diseases Gene expression Child Cancer Pediatric screening and diagnosis Leukemia medicine.diagnostic_test Stem cell transplantation Hematopoietic Stem Cell Transplantation Hematopoietic stem cell Myeloid leukemia Hematology Allografts Flow Cytometry Laboratory hematology Detection Leukemia Myeloid Acute medicine.anatomical_structure Residual Child Preschool 030220 oncology & carcinogenesis Female Unrelated Donors 4.2 Evaluation of markers and technologies Homologous Adult Pediatric Research Initiative medicine.medical_specialty Measurable residual disease Adolescent Pediatric Cancer Clinical Sciences Immunology Acute Article Disease-Free Survival Flow cytometry 03 medical and health sciences Rare Diseases Clinical Research Internal medicine Genetics medicine Humans Transplantation Homologous Preschool WT1 Proteins Transplantation business.industry Inflammatory and immune system Infant Newborn Infant Wilms' tumor Newborn Stem Cell Research medicine.disease Neoplasm business Cytometry 030215 immunology
Zdroj:	Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation, vol 24, iss 10
ISSN:	1083-8791
DOI:	10.1016/j.bbmt.2018.06.010
Popis:	We enrolled 150 patients in a prospective multi-center study of children with acute myeloid leukemia undergoing hematopoietic stem cell transplant (HSCT) comparing detection of measurable residual (MRD) disease by a “Difference from Normal” flow cytometry (ΔN) approach with assessment of Wilms tumor 1 (WT-1) gene expression without access to the diagnostic specimen. Prospective analysis of the specimens using this approach showed that 23% of patients being screened for HSCT had detectable residual disease by ΔN (0.04–53%). Of those patients who proceeded to transplant as being in morphologic remission, 10 had detectable disease (0.04–14%) by ΔN. The disease free survival of this group was 10% (0–35%), compared to 55% (46–64
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a379020b8e9c1b95677d4639bd292a8 https://doi.org/10.1016/j.bbmt.2018.06.010 Zobrazit plný text záznamu Full Text from ScienceDirect