Comparison of pathology sampling protocols for pancreatoduodenectomy specimens
| Autor: | Jacopo Ferro, Roberto Fiocca, Oneda Grami, Rita Bianchi, Federica Grillo, Alessandro Vanoli, Sara Delfanti, Luca Mastracci, Francesca Pitto, Leonardo Peñuela |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Multivariate analysis medicine.medical_treatment Gastroenterology Pathology and Forensic Medicine Lymph node ratio Pancreaticoduodenectomy Specimen Handling Sampling protocols 03 medical and health sciences 0302 clinical medicine Internal medicine medicine Humans Sampling (medicine) Stage (cooking) Molecular Biology Lymph node Survival analysis Retrospective Studies Pancreatic cancer Resection margins Lymph Nodes Margins of Excision Multivariate Analysis Pancreatic Neoplasms Prognosis business.industry Retrospective cohort study Cell Biology General Medicine 030104 developmental biology medicine.anatomical_structure 030220 oncology & carcinogenesis Resection margin business |
| Zdroj: | Virchows Archiv : an international journal of pathology. 476(5) |
| ISSN: | 1432-2307 |
| Popis: | Pancreatoduodenectomy is one of the most challenging surgical specimens for pathologists. Recently, two different, standardized protocols have been proposed: the axial slicing Leeds protocol (LP) and the bi-valving Adsay protocol (AP). Comparison between standardized and non-standardized protocols (NSP) was performed with emphasis on margin involvement and lymph node yield. Pancreatoduodenectomy cases were retrospectively recruited: 46 sampled with LP, 52 cases with AP and 46 cases with NSP. Clinico-pathologic data and rates of margin/surface involvement were collected and their prognostic influence on survival was assessed. Statistical differences between NSP and AP and LP were seen for nodal yield (p = 0.0001), N+ (p = 0.0001) and lymph node ratio - LNR (p |
| Databáze: | OpenAIRE |
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