The Safety of an Adjuvanted Autologous Cancer Vaccine Platform in Canine Cancer Patients
| Autor: | Nikolai Petrovsky, Annika Oksa, Christopher Weir, Zoe Walton-Weitz, Peter Mackenzie-Wood, Katrina Yee-Ka Cheng, Hope Richards, Peter Bennett, Nicola Kynoch, Felicia Tam, Miles Alexander, Rachel Allavena, Richard Naylor, Jennifer Millar |
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| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty medicine.medical_treatment Cancer therapy canine Canine cancer Booster dose autologous Article 03 medical and health sciences 0302 clinical medicine Immune system Antigen adjuvant Internal medicine vaccine Medicine Advax™ lcsh:Veterinary medicine General Veterinary business.industry Vaccination 030104 developmental biology 030220 oncology & carcinogenesis lcsh:SF600-1100 Cancer vaccine business Adjuvant |
| Zdroj: | Veterinary Sciences Veterinary Sciences, Vol 5, Iss 4, p 87 (2018) Volume 5 Issue 4 |
| ISSN: | 2306-7381 |
| Popis: | Canine cancer rates are similar to humans, though the therapeutic options might be limited. Inducing a patient&rsquo s own immune system to have an anti-tumor response is an attractive approach to cancer therapy. In this safety study, autologous tumor vaccines produced specifically for each canine patient were combined with Advax&trade a novel non-inflammatory immunomodulator and vaccine adjuvant and were tested for safety in a diverse range of patient presentations alone or in combination with other treatments. Canine patients had their tumor biopsied, debulked or resected and the tumor antigens were processed into an autologous vaccine formulated with Advax&trade adjuvant with or without rhizavidin as an additional immune stimulant. Patients treated early in the trial received two intramuscular (IM) doses, 2 weeks apart. As the study progressed and no issues of safety were observed, the protocol was changed to weekly vaccinations for 4 weeks followed by monthly booster shots. Over the 150 I.M injections delivered to date, the vaccine was found to be very safe and no significant adverse reactions were observed. These results justify ongoing development and future controlled studies of this autologous vaccine approach. |
| Databáze: | OpenAIRE |
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