IL28B polymorphisms are associated with severity of liver disease in human immunodeficiency virus (HIV) patients coinfected with hepatitis C virus
| Autor: | Amanda Fernández-Rodríguez, Juan Berenguer, María Guzmán-Fulgencio, Jaime Cosín, Pilar Miralles, Emilio Álvarez, Pilar Catalán, Mónica García-Álvarez, María Ángeles Jiménez-Sousa, Salvador Resino, Dariela Micheloud, Juan Carlos López |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Microbiology (medical) medicine.medical_specialty Linkage disequilibrium Genotype Hepatitis C virus HIV Infections Single-nucleotide polymorphism Hepacivirus medicine.disease_cause Polymorphism Single Nucleotide Severity of Illness Index Gastroenterology Linkage Disequilibrium Young Adult Liver disease Gene Frequency Internal medicine medicine Humans Allele Alleles medicine.diagnostic_test Coinfection business.industry Interleukins Hepatitis C Odds ratio Hepatitis C Chronic Middle Aged medicine.disease Virology Cross-Sectional Studies Infectious Diseases Liver Liver biopsy Female Interferons business |
| Zdroj: | Journal of Infection. 66:170-178 |
| ISSN: | 0163-4453 |
| DOI: | 10.1016/j.jinf.2012.10.025 |
| Popis: | Summary Objective To evaluate the association of IL28B polymorphisms and severity of liver disease among human immunodeficiency virus (HIV)/hepatitis C virus (HCV) coinfected patients. Methods We carried out a cross-sectional study on 223 patients. Liver biopsies were evaluated according to Metavir score. IL28B polymorphisms (rs12980275, rs8099917, rs7248668, and rs11881222) were genotyped using GoldenGate ® assay. Results IL28B polymorphisms were in strong linkage disequilibrium, especially the couples rs12980275/rs11881222 and rs8099917/rs7248668. For all patients, the rs12980275 A allele increased the odds for significant fibrosis ( F ≥ 2) odds ratio (OR) = 1.68; p = 0.018) and more rapid fibrosis progression (FPR ≥ 0.075 fibrosis units/year) (OR = 1.64; p = 0.035), and decreased the odds for liver steatosis (OR = 0.61; p = 0.046). Furthermore, the rs8099917 T allele increased the odds for F ≥ 2 (OR = 1.93; p = 0.020), FPR ≥ 0.075 (OR = 2.08; p = 0.021), and elevated ALT (≥80 IU/l) (OR = 1.78; p = 0.048). For HCV-genotype 1 patients, rs12980275 A and rs8099917 T alleles decreased the odds for liver steatosis (OR = 0.22; p p = 0.048; respectively). For HCV-genotype 3 patients, the rs12980275 A allele increased the odds for F ≥ 2 ((OR = 6.30; p = 0.012), FPR ≥ 0.075 (OR = 6.40; p = 0.025), and elevated ALT (OR = 4.12; p = 0.037); and the rs8099917 T allele also increased the odds for F ≥ 2 (OR = 7.56; p = 0.027), FPR ≥ 0.075 (OR = 50.8; p = 0.012), and elevated ALT (OR = 5.39; p = 0.043). However, we did not find significant trends in patients infected with HCV-genotype 4. Conclusion The major alleles of IL28B (rs12980275 A, rs11881222 A, rs8099917 T, and rs7248668 G) are associated with increased odds of liver disease severity in HIV patients infected with HCV-genotype 3. In contrast, HCV-genotype 1 patients carrying the major alleles of IL28B polymorphisms had lower odds for liver steatosis. |
| Databáze: | OpenAIRE |
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