Growth/differentiation factor-15: prostate cancer suppressor or promoter?
Autor: | Karel Souček, Petr Vaňhara, Aleš Hampl, Alois Kozubík |
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Rok vydání: | 2012 |
Předmět: |
Male
Cancer Research Growth Differentiation Factor 15 Urology Cellular differentiation medicine.medical_treatment Osteoclasts Bone Neoplasms Biology 03 medical and health sciences Prostate cancer 0302 clinical medicine Transforming Growth Factor beta medicine Humans Molecular Targeted Therapy Tissue homeostasis 030304 developmental biology Immunosuppression Therapy 0303 health sciences Cancer Prostatic Neoplasms Cell Differentiation medicine.disease 3. Good health Cytokine Oncology 030220 oncology & carcinogenesis Immunology Cancer research GDF15 Signal transduction Transforming growth factor Signal Transduction |
Zdroj: | Prostate cancer and prostatic diseases. 15(4) |
ISSN: | 1476-5608 |
Popis: | Deregulation of expression and function of cytokines belonging to the transforming growth factor-β (TGF-β) family is often associated with various pathologies. For example, this cytokine family has been considered a promising target for cancer therapy. However, the detailed functions of several cytokines from the TGF-β family that could have a role in cancer progression and therapy remain unclear. One of these molecules is growth/differentiation factor-15 (GDF-15), a divergent member of the TGF-β family. This stress-induced cytokine has been proposed to possess immunomodulatory functions and its high expression is often associated with cancer progression, including prostate cancer (PCa). However, studies clearly demonstrating the mechanisms for signal transduction and functions in cell interaction, cancer progression and therapy are still lacking. New GDF-15 roles have recently been identified for modulating osteoclast differentiation and for therapy for PCa bone metastases. Moreover, GDF-15 is as an abundant cytokine in seminal plasma with immunosuppressive properties. We discuss studies that focus on the regulation of GDF-15 expression and its role in tissue homeostasis, repair and the immune response with an emphasis on the role in PCa development. |
Databáze: | OpenAIRE |
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