Supplementary figures from Combination Therapy Targeting BCL6 and Phospho-STAT3 Defeats Intratumor Heterogeneity in a Subset of Non–Small Cell Lung Cancers

Autor: Lani F. Wu, Steven J. Altschuler, John D. Minna, Leandro Cerchietti, Fengtian Xue, Kimberley Avila, Long Shan Li, Rossella Marullo, Patrick D. Dospoy, Jill E. Larsen, Satwik Rajaram, Dhruba Deb
Rok vydání: 2023
DOI: 10.1158/0008-5472.22413797
Popis: This file shows all the supplementary figures as follows: Supplementary Figure 1: Clonal variability introduced by the TP53, KRAS, and MYC manipulations Supplementary Figure 2: Quantitation of signaling alterations for beta-CATENIN, P65, FOXO1 and p-ERK1/2 Supplementary Figure 3: Comparison between parental HBEC and HBECPKM cells for their sensitivity to the MEK inhibitor AZD6244 Supplementary Figure 4: Similar distributions of SMAD2/3 signaling with total or phospho antibodies Supplementary Figure 5: Alterations of p-STAT3 signaling in high EGF growth condition Supplementary Figure 6: Identification of lower EGF concentration (
Databáze: OpenAIRE