A Negative Direct Antiglobulin Test with Strong IgG Red Cell Autoantibodies Present in the Serum of a Patient with Autoimmune Haemolytic Anaemia
| Autor: | C. P. Engelfriet, M. B. Van't Veer, M. A. M. Overbeeke, A. E. G. Kr. von dem Borne, P. M. V. Van Wieringen, I. van Leeuwen |
|---|---|
| Rok vydání: | 1981 |
| Předmět: |
Male
Erythrocytes Rh-Hr Blood-Group System Adolescent Red Cell business.industry Recent episode Autoantibody Hematology Haemolysis Hemolysis Coombs Test Antibody Specificity Immunoglobulin G Immunology Hemoglobinometry Humans Medicine Anemia Hemolytic Autoimmune Rh phenotype business Direct antiglobulin test Autoantibodies |
| Zdroj: | British Journal of Haematology. 49:383-386 |
| ISSN: | 1365-2141 0007-1048 |
| DOI: | 10.1111/j.1365-2141.1981.tb07240.x |
| Popis: | Summary. The case is presented of a boy with an autoimmune haemolytic anaemia of 10 years duration. He had a positive direct antiglobulin test with IgG and complement detected on the red cells and with IgG autoantibodies in the serum. During a recent episode of severe haemolysis, the Hb level fell to 3.8 g/dl and the direct antiglobulin test became negative although his autoantibodies still reacted with all the red cells in a panel. The serum reacted more strongly with C- and e-positive cells. The Rh phenotype of the patient was CcDee as it had always been. Possible explanations of the unexpected findings are discussed. |
| Databáze: | OpenAIRE |
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