Malnutrition in Alzheimer’s Disease, Dementia with Lewy Bodies, and Frontotemporal Lobar Degeneration: Comparison Using Serum Albumin, Total Protein, and Hemoglobin Level

Autor: Ryuji Fukuhara, Shuji Todani, Yusuke Miyagawa, Noboru Fujise, Mamoru Hashimoto, Kengo Matsukuma, Asuka Koyama, Noriko Hasegawa, Yutaka Hatada, Masateru Matsushita, Manabu Ikeda, Hibiki Tanaka, Michiyo Kawano
Jazyk: angličtina
Rok vydání: 2016
Předmět:
Male
Pathology
Dementia with Lewy bodies
lcsh:Medicine
Biochemistry
Hemoglobins
0302 clinical medicine
Weight loss
Outpatients
Medicine and Health Sciences
Odds Ratio
Prevalence
Medicine
030212 general & internal medicine
lcsh:Science
Aged
80 and over
education.field_of_study
Multidisciplinary
Neurodegenerative Diseases
Frontotemporal lobar degeneration
Neurology
Caregivers
Female
Alzheimer's disease
medicine.symptom
Research Article
Lewy Body Disease
medicine.medical_specialty
Population
03 medical and health sciences
Alzheimer Disease
Diagnostic Medicine
Internal medicine
Albumins
mental disorders
Mental Health and Psychiatry
Dementia
Humans
Hemoglobin
education
Serum Albumin
Nutrition
Aged
business.industry
lcsh:R
Malnutrition
Biology and Life Sciences
Proteins
Odds ratio
medicine.disease
nervous system diseases
lcsh:Q
Frontotemporal Lobar Degeneration
business
030217 neurology & neurosurgery
Biomarkers
Zdroj: PLoS ONE
PLoS ONE, Vol 11, Iss 6, p e0157053 (2016)
ISSN: 1932-6203
Popis: Malnutrition among dementia patients is an important issue. However, the biochemical markers of malnutrition have not been well studied in this population. The purpose of this study was to compare biochemical blood markers among patients with Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and frontotemporal lobar degeneration (FTLD). A total of 339 dementia outpatients and their family caregivers participated in this study. Low serum albumin was 7.2 times more prevalent among patients with DLB and 10.1 times more prevalent among those with FTLD than among those with AD, with adjustment for age. Low hemoglobin was 9.1 times more common in female DLB patients than in female AD patients, with adjustment for age. The levels of biochemical markers were not significantly correlated with cognitive function. Family caregivers of patients with low total protein, low albumin, or low hemoglobin were asked if the patients had loss of weight or appetite; 96.4% reported no loss of weight or appetite. In conclusion, nutritional status was worse in patients with DLB and FTLD than in those with AD. A multidimensional approach, including blood testing, is needed to assess malnutrition in patients with dementia.
Databáze: OpenAIRE
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