Circulating Endotoxin and Cytokines after Cardiopulmonary Bypass: Differential Correlation with Duration of Bypass and Systemic Inflammatory Response/Multiple Organ Dysfunction Syndromes
| Autor: | Edward Devol, Salah Al-Gain, Zuhair Al-Halees, Mahmoud Elbarbary, Fareed Khouqeer, Khalid S.A. Khabar |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Lipopolysaccharides
Male medicine.medical_specialty Time Factors Multiple Organ Failure Immunology Inflammation Gastroenterology Pathology and Forensic Medicine law.invention Proinflammatory cytokine law Intensive care Internal medicine medicine Cardiopulmonary bypass Coagulopathy Humans Immunology and Allergy Cardiopulmonary Bypass Interleukin-6 Tumor Necrosis Factor-alpha business.industry Interleukin-8 Organ dysfunction Prognosis medicine.disease Endotoxins Systemic inflammatory response syndrome Child Preschool Cytokines Female medicine.symptom Multiple organ dysfunction syndrome business Interleukin-1 |
| Zdroj: | Clinical Immunology and Immunopathology. 85:97-103 |
| ISSN: | 0090-1229 |
| DOI: | 10.1006/clin.1997.4413 |
| Popis: | Cardiopulmonary bypass constitutes an injury that may cause postoperative pathophysiological changes due to systemic inflammatory response syndrome (SIRS) and multiple organ dysfunction syndrome (MODS). These complications include coagulopathy, hypotension, capillary leakage, and multiple organ injury. To investigate the role of endotoxin and cytokines in the response to bypass injury, we measured plasma levels of endotoxin and proinflammatory cytokines in 20 pediatric patients before and after bypass. Clinical data, including duration of injury and tests indicative of SIRS/MODS, were collected. Levels of endotoxin, TNF-alpha, IL-6, and IL-8 but not IL-1 beta were significantly increased after bypass. Most of the cytokines have been found to correlate with each other. Endotoxin did not correlate with duration of bypass, cytokines, or SIRS/MODS. In contrast, TNF-alpha and IL-8 correlated with duration of bypass and were associated with SIRS/MODS. Certain clinical complications were associated with specific cytokines. Understanding the role of cytokinemia in SIRS/MODS may lead to better prognostic assessment and therapeutic modalities. |
| Databáze: | OpenAIRE |
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