Soluble suppression of tumorigenicity-2 predicts pneumonia in patients with inhalation injury: Results of a pilot study
| Autor: | Joan R. Masclans, Judith Marin-Corral, Jacinto Baena, Bruce Dos Santos, Patricia Guilabert, Juan P. Barret, Oriol Roca, Mireia Ruiz-Castilla, Claudia Vizcaíno |
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| Rok vydání: | 2021 |
| Předmět: |
Male
Reconstructive surgery medicine.medical_specialty Burn injury Carcinogenicity Tests Pilot Projects Inflammation Critical Care and Intensive Care Medicine Gastroenterology Statistics Nonparametric 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Internal medicine Odds Ratio medicine Humans Hospital Mortality Prospective Studies Interleukin 8 Retrospective Studies Chi-Square Distribution business.industry Incidence (epidemiology) 030208 emergency & critical care medicine Pneumonia General Medicine Middle Aged Smoke Inhalation Injury medicine.disease Interleukin-1 Receptor-Like 1 Protein Spain Inhalation injury Cohort Emergency Medicine Female Surgery medicine.symptom business Biomarkers |
| Zdroj: | Burns. 47:906-913 |
| ISSN: | 0305-4179 |
| Popis: | Several mechanisms play a role in the development of pneumonia after inhalation injury. Our aim was to analyze whether higher concentrations of inflammatory markers or of biomarkers of epithelial injury are associated with a higher incidence of pneumonia in patients with inhalation injury.Secondary analysis of a single-center prospective observational cohort pilot study, performed over a two-year period (2015-2017) at the Burns Unit of the Plastic and Reconstructive Surgery Department of Vall d'Hebron University Hospital. All patients aged 18 with suspected inhalation injury undergoing admission to the Burns Unit were included. Plasma biomarkers of the lung epithelium (RAGE and SP-D), inflammation markers (IL6, IL8), and IL33, as well as soluble suppression of tumorigenicity-2 (sST2) levels, were measured within the first 24 h of admission.Twenty-four patients with inhalation injury were included. Eight (33.3%) developed pneumonia after a median of 7 (4-8) days of hospital stay. Patients with pneumonia presented higher plasma concentrations of sST2 (2853 [2356-3351] ng/mL vs 1352 [865-1839] ng/mL; p0.001), IL33 (1.95 [1.31-2.59] pg/mL vs 1.26 [1.07-1.45] pg/mL; p = 0.002) and IL8 (325.7 [221.6-430.0] pg/mL vs 174.1 [95.2-253.0] pg/mL; p = 0.017) on day 1 of inclusion. Plasma sST2 concentration in the first 24 h demonstrated excellent diagnostic accuracy for predicting the occurrence of pneumonia in patients with smoke inhalation (AUROC 0.929 [95%CI 0.818-1.000]). A cutoff point of ≥2825 ng/mL for sST2 had a sensitivity of 75% and a specificity of 100%. The risk ratio of pneumonia in patients with sST2 ≥ 2825 ng/mL was 7.14 ([95% CI 1.56-32.61]; p = 0.016).Plasma sST2 in the first 24 h of admission predicts the occurrence of pneumonia in patients with inhalation injury. |
| Databáze: | OpenAIRE |
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