Plasma phospholipid fatty acid composition and desaturase activity in women with gestational diabetes mellitus before and after delivery

Autor: Giovanni Sartore, M. G. Dalfrà, A. Barison, Eugenio Ragazzi, Annunziata Lapolla, Silvia Burlina, Raffaella Marin
Jazyk: angličtina
Rok vydání: 2017
Předmět:
0301 basic medicine
Fatty Acid Desaturases
endocrine system diseases
Endocrinology
Diabetes and Metabolism
Gestational diabetes mellitus
chemistry.chemical_compound
0302 clinical medicine
Endocrinology
Pregnancy
Hyperinsulinemia
Phospholipids
chemistry.chemical_classification
Fatty Acids
General Medicine
Diet Records
Gestational diabetes
Diabetes and Metabolism
C-Reactive Protein
Cholesterol
Cytokines
Female
medicine.symptom
Adult
medicine.medical_specialty
Pregnancy Trimester
Third
Phospholipid
030209 endocrinology & metabolism
Inflammation
03 medical and health sciences
Downregulation and upregulation
Plasma phospholipid fatty acids
Diabetes mellitus
Internal medicine
medicine
Internal Medicine
Humans
Desaturase activity
business.industry
nutritional and metabolic diseases
Fatty acid
Glucose Tolerance Test
medicine.disease
Diabetes
Gestational
030104 developmental biology
chemistry
business
Popis: Analyze plasma phospholipid fatty acids (PPFA) composition and desaturase activity in women with gestational diabetes (GDM) and in women with a normal glucose tolerance (NGT) before and after delivery, and to evaluate the possible relationship between desaturase activity and inflammatory parameters. PPFA composition was analyzed by gas chromatography in 21 women with GDM and from 21 with NGT, during the third trimester of pregnancy and 6 months after delivery. We used fatty acid product-to-precursor ratios to estimate desaturase activity, and we also measured in all women interleukins six and ten, tumor necrosis factor alpha and C-reactive protein. No significant differences were observed between NGT and GDM women in terms of PPFA composition, both in pregnancy and after pregnancy. Estimated desaturase Δ9-18 activity was significantly higher, and estimated desaturase Δ5 activity was significantly lower during pregnancy in all women. We observed no correlations between inflammatory markers and desaturases activity, during or after pregnancy, in both groups. Our data suggest that GDM does not influence PPFA composition and desaturase activity during pregnancy. In addition, late pregnancy characterized by hyperinsulinemia appears to upregulate desaturase Δ9-18 activity in NGT and GDM women.
Databáze: OpenAIRE
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